Document Detail


Endoscopic treatment of chronic pancreatitis: a multicenter study of 1000 patients with long-term follow-up.
MedLine Citation:
PMID:  12244496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND STUDY AIMS: Endoscopic ductal decompression therapy has become an established method of treating patients with painful obstructive chronic pancreatitis. Smaller series, mostly with a medium-term follow-up period, have reported encouraging results. The present analysis presents long-term follow-up data from a large multicenter patient cohort. PATIENTS AND METHODS: Patients with painful chronic pancreatitis and with ductal obstruction due to either strictures and/or stones treated endoscopically at eight different centers underwent follow-up after 2 - 12 years (mean 4.9 years). The patients' clinical data, the rate of technical success, and complications were recorded from the charts. Follow-up data were prospectively obtained using structured questionnaires; the main parameter for evaluating treatment success was a significant reduction in pain (no pain or only weak pain). RESULTS: Follow-up data were obtained from 1018 of 1211 patients treated (84%) with mainly strictures (47%), stones (18%), or strictures plus stones (32%). At the long-term follow-up, 60% of the patients had their endotherapy completed, 16% were still receiving some form of endoscopic treatment, and 24% had undergone surgery. The long-term success of endotherapy was 86% in the entire group, but only 65% in an intention-to-treat analysis. There were no significant differences between the patient groups with regard to either strictures, stones, or both. Pancreatic function was not positively affected by endoscopic therapy. CONCLUSIONS: Endoscopic ductal decompression therapy offers relief of pain in two-thirds of the patients when it is used as the only form of treatment. One-quarter of the patients have to undergo surgery.
Authors:
T Rösch; S Daniel; M Scholz; K Huibregtse; M Smits; T Schneider; C Ell; G Haber; J-F Riemann; R Jakobs; R Hintze; A Adler; H Neuhaus; M Zavoral; F Zavada; V Schusdziarra; N Soehendra;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Endoscopy     Volume:  34     ISSN:  0013-726X     ISO Abbreviation:  Endoscopy     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-23     Completed Date:  2003-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  765-71     Citation Subset:  IM    
Affiliation:
Dept of Internal Medicine II, Technical University of Munich, München, Germany. Thomas.Roesch@lrz.tu-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Cholangiopancreatography, Endoscopic Retrograde*
Chronic Disease
Decompression, Surgical
Drainage
Female
Follow-Up Studies
Humans
Male
Middle Aged
Pain / therapy
Pancreatic Ducts / physiopathology,  surgery*
Pancreatitis / physiopathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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