Document Detail

Endoscopic resection of adenoma-like mass in chronic ulcerative colitis using a combined endoscopic mucosal resection and cap assisted submucosal dissection technique.
MedLine Citation:
PMID:  18465807     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Resection of an adenoma-like mass (ALM) in chronic ulcerative colitis (CUC) complicated by mucosal fibrosis has historically not been technically feasible. Endoscopic submucosal dissection techniques may now provide a therapeutic tool enabling the division of submucosal fibrotic scarring, hence enabling endoluminal resection for the first time in this select patient group. The aim was prospective evaluation of endoscopic submucosal dissection-assisted (ESD) resection of flat, sessile, and lateral spreading tumors in CUC complicated by submucosal desmoplasis. Clinical endpoints were postresection recurrence rates, R0 resection status, and complications. METHODS: ESD-assisted endoscopic mucosal resection (EMR) using the Olympus KD-630L insulation-tipped knife was performed on selected lesions. RESULTS: Sixty-nine patients met inclusion criteria, of which 2 were excluded due to follow-up default. En bloc resection was performed in 52/67 (78%) cases with 15/67 (7%) requiring a piecemeal approach. R0 resection was achieved in 49/52 (94%) of lesions undergoing en bloc resection (perforation rate 2/67 [3%]). Bleeding complications occurred in 7/67 (10%) of cases. No metachronous circumscribed intraepithelial neoplastic lesions or cancer was detected at follow-up. At a median of 18 months follow-up, overall cure rates for the ESD-assisted EMR cohort was 66/67 (98%). CONCLUSIONS: We have shown for the first time that endoscopic resection of ALM even in the presence of complicating mucosal fibrosis is technically achievable using a combined ESD-assisted EMR technique. In an appropriately selected cohort, this technique may provide a technically feasible and clinically acceptable therapy where otherwise colectomy would be required.
Lesley-Ann Smith; Wal Baraza; Nick Tiffin; Simon S Cross; David P Hurlstone
Related Documents :
22677347 - Thoracoscopic versus open pulmonary metastasectomy: a prospective, sequentially control...
22387127 - On chronic rhinosinusitis and the prevalence of fungal sinus disease: problems of diagn...
22447207 - Management of chylous fistula after neck dissection using negative-pressure wound thera...
22865807 - Atropine sulphate: rescue therapy for pyloric stenosis.
19436617 - Treatment and chemoprevention of nsaid-associated gastrointestinal complications.
21458127 - Maxillectomy through mandibulotomy-a retrospective clinical review.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  14     ISSN:  1536-4844     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-17     Completed Date:  2009-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1380-6     Citation Subset:  IM    
Department of Gastroenterology, General Infirmary at Leeds, Leeds, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenoma / pathology,  surgery*
Chronic Disease
Cohort Studies
Colitis, Ulcerative / pathology,  surgery*
Colon / pathology,  surgery*
Colonic Neoplasms / pathology,  surgery*
Colonoscopy / methods*
Follow-Up Studies
Intestinal Mucosa / surgery
Middle Aged
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Radiation risks from imaging studies in children with cancer.
Next Document:  Two cases of pregnant women with ovarian endometrioma mimicking a malignant ovarian tumor.