Document Detail

Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients.
MedLine Citation:
PMID:  10650267     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pancreatic blood flow is diminished in experimental models of acute and chronic pancreatitis. We attempted to develop a safe and reliable technique for its measurement in patients and to examine blood flow in patients with chronic pancreatitis and in control subjects. METHOD: Pancreatic blood flow was measured using the hydrogen gas clearance technique and an endoscopically placed platinum ductal electrode. Pancreatic blood flow was measured in 12 patients with chronic pancreatitis diagnosed clinically and radiographically, and in 11 control patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) for non-pancreatic pathology. RESULTS: Patients with chronic pancreatitis had a significantly lower pancreatic blood flow compared with control patients (51.5 versus 91.7 mL/min/100 gm, p < 0.01). With secretin stimulation pancreatic blood flow increased in two control patients, whereas this notable rise was not seen in three patients with chronic pancreatitis. CONCLUSIONS: Measurement of pancreatic blood flow with an endoscopically placed electrode is relatively safe and simple to perform. The scarring and vascular fibrosis associated histologically with chronic pancreatitis is reflected in lower pancreatic blood flow.
M P Lewis; S K Lo; P U Reber; A Patel; B Gloor; K E Todd; M T Toyama; S Sherman; S W Ashley; H A Reber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  51     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-02     Completed Date:  2000-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Department of Surgery, Addenbrookes Hospital, Cambridge, United Kingdom.
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MeSH Terms
Blood Flow Velocity
Cholangiopancreatography, Endoscopic Retrograde
Chronic Disease
Hydrogen / diagnostic use
Middle Aged
Pancreas / blood supply*
Pancreatic Ducts
Pancreatitis / diagnosis,  physiopathology*
Reg. No./Substance:
1333-74-0/Hydrogen; 7440-06-4/Platinum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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