Document Detail


Endoscopic instrumented posterolateral lumbar fusion with Healos and recombinant human growth/differentiation factor-5.
MedLine Citation:
PMID:  14683555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The goal of this study was to use a minimally invasive endoscopic surgical technique in a sheep model to evaluate the efficacy of an osteoinductive growth factor, recombinant human growth/differentiation factor-5 (also designated MP52), and an osteoconductive matrix formulation (Healos; DePuy AcroMed, Inc., Mountain View, CA) for inducing and facilitating bone formation. METHODS: Twelve mature sheep underwent bilateral posterolateral lumbar fusion and pedicle screw fixation via a posterior endoscopic approach. Each sheep received two different types of graft material, autogenous iliac crest bone, or a bone graft substitute (MP52 with Healos), inserted into the right and left sides of the spine in an alternating fashion. Groups of four sheep were killed at 2, 4, and 6 months postoperatively for manual, radiographic, and histological evaluation. RESULTS: No neurological impairments, infections, or other complications were observed. After 2 months, partial fusion on both sides was observed, but radiographic evaluation showed greater bone growth on the side that received the bone graft substitute. Solid posterolateral fusion was observed in both autograft and bone graft substitute sites at 4 and 6 months, and autograft and Healos MP52 fusion sites were essentially the same at histological examination. There was no abnormal overgrowth of new bone from either of these two materials. CONCLUSION: Endoscopic posterolateral lumbar arthrodesis and instrumentation is feasible, safe, and effective in a sheep model. Healos is a useful bonding agent that mimics natural bone in posterolateral intertransverse fusion sites. Combined with MP52, it produced fusion comparable to that of autogenous bone graft. Minimally invasive techniques and bone graft substitutes could eliminate morbidity and increase the likelihood of successful fusion.
Authors:
Tae-Ahn Jahng; Tsai-Sheng Fu; Bryan W Cunningham; Anton E Dmitriev; Daniel H Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurosurgery     Volume:  54     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-19     Completed Date:  2004-03-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-80; discussion 180-1     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Morphogenetic Proteins / administration & dosage*
Bone Screws
Bone Substitutes / administration & dosage*
Bone Transplantation
Collagen Type I / administration & dosage*
Growth Differentiation Factor 5
Lumbar Vertebrae / pathology,  surgery*
Models, Animal
Neuroendoscopy / methods*
Recombinant Proteins / administration & dosage
Sheep
Spinal Fusion / methods*
Time Factors
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Bone Substitutes; 0/Collagen Type I; 0/GDF5 protein, human; 0/Growth Differentiation Factor 5; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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