Document Detail

Endoscopic identification of Peyer's patches of the terminal ileum in a patient with Crohn's disease.
MedLine Citation:
PMID:  15309739     Owner:  NLM     Status:  MEDLINE    
We presented a 20-year-old patient with Crohn's disease (CD). Colonoscopy revealed longitudinal ulceration in the terminal ileum and rectal aphtoid ulcers. After treatment with mesalamine and total parenteral nutrition, repeat colonoscopy revealed a granular elevated area in the terminal ileum, which appeared as an irregular dome-like elevation with irregularly arranged villi on magnifying endoscopy. Biopsy specimens taken from the region showed microgranulomas and lymphoid hyperplasia. Scanning electron microscopy revealed the presence of M cells, confirming that the area corresponded to Peyer's patches. Peyer's patches by magnifying endoscopy and electron microscopy may provide insights into the pathogenesis of CD.
Hiroshi Ishimoto; Hajime Isomoto; Saburo Shikuwa; Chun-Yang Wen; Takashi Suematu; Masahiro Ito; Ikuo Murata; Hiromi Ishibashi; Shigeru Kohno
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  10     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-13     Completed Date:  2004-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2767-8     Citation Subset:  IM    
Department of Internal Medicine, National Nagasaki Medical Center, 2-1001 Kubara, Omura, Nagasaki 856-8562, Japan.
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MeSH Terms
Crohn Disease / pathology*
Endoscopes, Gastrointestinal
Ileum / pathology*
Intestinal Mucosa / pathology,  ultrastructure
Microscopy, Electron, Scanning
Peyer's Patches / pathology*,  ultrastructure

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