Document Detail


Endoscopic flushing with pronase improves the quantity and quality of gastric biopsy: a prospective study.
MedLine Citation:
PMID:  25019968     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and study aims: Pronase, a proteolytic enzyme, is known to improve mucosal visibility during esophagogastroduodenoscopy (EGD), but little is known about its effects on gastric biopsy. This study assessed whether endoscopic flushing with pronase improves the quality of gastric biopsy. Patients and methods: Consecutive patients who underwent EGD were randomly assigned to either the control group or the pronase group in a prospective setting. The first biopsy of the identified lesion was performed during endoscopy. Endoscopic flushing with either 50 mL of water and dimethylpolysiloxane (DMPS; control group) or 50 mL of water, pronase, sodium bicarbonate, and DMPS (pronase group) was then applied to the lesion. After 5 minutes, the second biopsy was performed 2 - 3 mm away from the first biopsy site. The thickness of mucus, depth of the specimen, overall diagnostic adequacy, anatomical orientation, and crush artifact were measured to assess the quality of the biopsy. Results: Of the 208 patients, 10 were not analyzed due to the absence of an identifiable lesion. Compared with the control group, the pronase group showed significantly decreased thickness of mucus (P < 0.001), increased depth of biopsy (P < 0.001), improved anatomical orientation (P = 0.010), and improved overall diagnostic assessment (P = 0.011) in the second biopsied specimen following endoscopic flushing. The crush artifact and hemorrhage did not differ between the groups. Conclusions: Endoscopic flushing with pronase not only improved the depth of biopsy but also the anatomical orientation and overall diagnostic adequacy. Pronase can be recommended for flushing during EGD to improve the quantity and quality of biopsy.
Authors:
Sun-Young Lee; Hye S Han; Jae M Cha; Yu K Cho; Gwang H Kim; Il-Kwun Chung
Related Documents :
3229388 - The significance of unexplained dilated common bile duct at endoscopic retrograde chola...
24036408 - Simplified dispatcher instructions improve bystander chest compression quality during s...
24594318 - Sacral nerve stimulation for the treatment of severe faecal incontinence: results after...
23350828 - Long-term outcome and quality of life after arterial switch operation: a prospective st...
18800998 - Internal carotid artery stenting in patients over 80 years of age: single-center experi...
2393058 - A reappraisal of appendicitis in the elderly.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-14
Journal Detail:
Title:  Endoscopy     Volume:  -     ISSN:  1438-8812     ISO Abbreviation:  Endoscopy     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Predicting Local Dengue Transmission in Guangzhou, China, through the Influence of Imported Cases, M...
Next Document:  Randomized controlled trial comparing efficacy and acceptability of split- and standard-dose sodium ...