| Endoscopic fluorescence detection of high-grade dysplasia in Barrett's esophagus. | |
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MedLine Citation:
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PMID: 8698231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Early detection and treatment of esophageal cancer in Barrett's esophagus may improve patient survival if dysplasia is effectively detected at endoscopy. Typically, four-quadrant pinch biopsy specimens are taken at 2-cm intervals. This study was conducted to determine whether laser-induced fluorescence spectroscopy could be used to detect high-grade dysplasia in patients with Barrett's esophagus. METHODS: Four hundred ten-naonometer laser light was used to induce autofluorescence of Barrett's mucosa in 36 patients. The spectra were analyzed using the differential normalized fluorescence (DNF) index technique to differentiate high-grade dysplasia from either low-grade or nondysplastic mucosa. Each spectrum was classified as either premalignant or benign using two different DNF indices. RESULTS: Analysis of the fluorescence spectra from all patients collectively using the DNF intensity at 480 nm (DNF480) index showed that 96% of nondysplastic Barrett's esophagus samples were classified as benign, all low-grade dysplasia samples as benign, 90% of high-grade dysplasia samples as premalignant, and 28% of low-grade with focal high-grade dysplasia samples as premalignant. Using the two DNF indices concurrently, all patients with any high-grade dysplasia were classified correctly. CONCLUSIONS: Laser-induced fluorescence spectroscopy has great potential to detect high-grade dysplasia in Barrett's esophagus when using the DNF technique. |
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Authors:
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M Panjehpour; B F Overholt; T Vo-Dinh; R C Haggitt; D H Edwards; F P Buckley |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 111 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-30 Completed Date: 1996-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 93-101 Citation Subset: AIM; IM |
Affiliation:
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Laser Center, Thompson Cancer Survival Center, Knoxville, Tennessee, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Barrett Esophagus / pathology* Esophageal Neoplasms / pathology Esophagoscopy Esophagus / pathology* Female Humans Lasers / diagnostic use Male Middle Aged Precancerous Conditions / pathology Spectrometry, Fluorescence / instrumentation, methods |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 1996 Jul;111(1):247-9
[PMID:
8698207
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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