Document Detail


Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement.
MedLine Citation:
PMID:  20872966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate the endoscopic manifestations and prognoses of gastrointestinal (GI) mantle cell lymphoma (MCL).
METHODS: A database search at the Department of Pathology of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences revealed 57 MCL patients with GI involvement. Clinical records were available for 35 of the 57 patients from 21 institutions, and those 35 patients were enrolled in this study. We summarized the gross types of endoscopic features, event-free survival (EFS), and overall survival (OS) of those patients.
RESULTS: Of the 35 patients, GI involvement in the esophagus, stomach, and duodenum was found in 2 (5.7%), 26 (74.3%), and 12 (34.3%) patients, respectively. Twenty-one of the 35 patients underwent colonoscopy; among them, GI involvement in the ileum, cecum, colon, and rectum was found in 10 (47.6%), 3 (14.3%), 12 (57.1%), and 10 (47.6%), respectively. Various lesions, such as superficial, protruded, fold thickening, or ulcerative, were found in the stomach, whereas multiple lymphomatous polyposis (MLP) was dominant from the duodenum to the rectum. Twelve patients were treated with a hyper-CVAD/MA regimen, and they had better OS (3-year rate, 88.3% vs 46.4%, P < 0.01) and better EFS (3-year rate, 66.7% vs 33.8%, P < 0.05) than the remaining 23 patients who were not treated with this regimen.
CONCLUSION: MLP was a representative form of intestinal involvement, whereas a variety of lesions were found in the stomach. The hyper-CVAD/MA regimen may improve survival in these patients.
Authors:
Masaya Iwamuro; Hiroyuki Okada; Yoshiro Kawahara; Katsuji Shinagawa; Toshiaki Morito; Tadashi Yoshino; Kazuhide Yamamoto
Related Documents :
6576756 - The eea stapler in colorectal surgery: a wellington experience.
18647926 - Chronic diverticulitis: clinical, radiographic, and pathologic findings.
17298626 - Persistent symptoms of functional outlet obstruction after rectocele repair.
9094016 - Segmental colonic motility in patients with anorectal malformations.
18264936 - Heart rate variability is decreased in chronic kidney disease but may improve with hemo...
22784196 - Do silent infarcts modify the effect of thrombolysis for stroke?
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-28     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4661-9     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. iwamuromasaya@yahoo.co.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antineoplastic Agents / therapeutic use
Databases, Factual
Endoscopy, Gastrointestinal*
Female
Gastrointestinal Neoplasms / diagnosis,  pathology*,  therapy
Humans
Lymphoma, Mantle-Cell / diagnosis,  pathology*,  therapy
Male
Middle Aged
Prognosis
Survival Rate
Chemical
Reg. No./Substance:
0/Antineoplastic Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Roles of liver innate immune cells in nonalcoholic fatty liver disease.
Next Document:  Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal ...