Document Detail


Endoscopic cyanoacrylate injection for the treatment of bleeding gastric varices: the first Iranian series.
MedLine Citation:
PMID:  22369304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Gastric varices are a major cause of gastrointestinal bleeding and death in patients with portal hypertension. N-butyl-2-cyanoacrylate injection is a new method for controlling bleeding gastric varices. This study aims to investigate the prognosis and complications of cyanoacrylate therapy for bleeding gastric varices.
METHODS: We conducted a prospective study between May 2009 and January 2010 at our center affiliated with the Shiraz University of Medical Sciences, Shiraz, Iran. All patients with gastric variceal bleeding were enrolled in the study. N-butyl-2-cyanoacrylate injection was performed for treatment of the bleeding, and patients underwent monthly endoscopies to determine the outcomes.
RESULTS: There were 13 patients with portal hypertension and gastric variceal bleeding included in the study. Initial hemostasis was obtained in all patients but more than one injection was needed in seven patients. Two patients developed re-bleeding and two died of advanced cirrhosis and other accompanying diseases. 
CONCLUSION: No major complications were observed after treatment with N-butyl-2-cyanoacrylate. This method can be safely used in treatment of gastric variceal bleeding.
Authors:
Seyed Alireza Taghavi; Ahad Eshraghian; Laleh Hamidpour; Mohammad Jafar Moshfe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  15     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-06-19     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  157-61     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adult
Enbucrilate / administration & dosage*,  adverse effects
Esophageal and Gastric Varices / therapy*
Female
Gastrointestinal Hemorrhage / etiology,  therapy*
Hemostasis, Endoscopic / methods*
Humans
Hypertension, Portal / complications
Iran
Liver Cirrhosis / complications
Male
Middle Aged
Prospective Studies
Sclerotherapy / methods*
Tissue Adhesives / administration & dosage*,  adverse effects
Treatment Outcome
Chemical
Reg. No./Substance:
0/Tissue Adhesives; 6606-65-1/Enbucrilate

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