| Endoscopic sedation of patients with chronic liver disease. | |
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MedLine Citation:
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PMID: 20682228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endoscopic procedures are often necessary in patients with chronic liver disease. The preprocedure evaluation of such patients should include an assessment of hepatic synthetic function and identification of neuropsychiatric findings suggestive of hepatic encephalopathy. It may be possible, in some cases, to perform diagnostic esophagogastroduodenoscopy without administration of sedation; this is desirable to eliminate the risks of sedation, especially encephalopathy. Nonetheless, most patients undergoing upper and lower endoscopy require sedation. Currently, the use of propofol is preferred to benzodiazepines and opioids for endoscopic sedation of patients with advanced liver disease due to its short biologic half-life and low risk of provoking hepatic encephalopathy. In appropriately selected patients, gastroenterologist-directed propofol administration seems safe. |
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Authors:
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Neville Bamji; Lawrence B Cohen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in liver disease Volume: 14 ISSN: 1557-8224 ISO Abbreviation: Clin Liver Dis Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9710002 Medline TA: Clin Liver Dis Country: United States |
Other Details:
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Languages: eng Pagination: 185-94 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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pharmacology Anesthetics, Intravenous / pharmacology Benzodiazepines / pharmacology Chronic Disease Conscious Sedation / adverse effects*, contraindications, methods Drug Administration Routes Endoscopy, Gastrointestinal / adverse effects, methods* Humans Hypnotics and Sedatives / pharmacology* Liver Diseases / diagnosis*, drug therapy Propofol / pharmacology* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 12794-10-4/Benzodiazepines; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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