| Endoscopic SIS injection into the lower oesophageal sphincter in dogs. | |
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MedLine Citation:
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PMID: 12760458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine the usefulness of endoscopically-delivered small intestinal submucosa (SIS) as a scaffold in enhancing the lower oesophageal sphincter (LOS) pressures. METHODS: Six dogs were endoscopically injected--four with the SIS and two with its glycerin carrier. Manometry was performed prior to injection and every four weeks post-op. RESULTS: Adequate and site correct injections were made in four dogs. In one dog, significant augmentation of pressures were obtained at four weeks. None had significant changes in pressure at eight weeks, differences in length at either four or eight weeks or significant differences in the thickness of the examined layers. Four of the six had capillary cushions on pathological examination. The dog injected with the carrier had a loose and disorganise collection, while the others were well organised. CONCLUSION: SIS is a biologically compatible material. Lack of an animal model for gastro-oesophageal reflux disease (GORD) makes determining the ability of injections of SIS to combat reflux problematic. |
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Authors:
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R E Marsh; Z T Awad; D A Cornet; T Tomonaga; T Smyrk; C J Filipi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Irish journal of medical science Volume: 172 ISSN: 0021-1265 ISO Abbreviation: Ir J Med Sci Publication Date: 2003 Jan-Mar |
Date Detail:
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Created Date: 2003-05-22 Completed Date: 2003-06-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7806864 Medline TA: Ir J Med Sci Country: Ireland |
Other Details:
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Languages: eng Pagination: 20-3 Citation Subset: IM |
Affiliation:
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Department of Surgery, Creighton University, NE, Omaha 68131, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Endoscopy Esophagogastric Junction / surgery* Gastroesophageal Reflux / therapy* Intestinal Mucosa / transplantation* Manometry |
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