Document Detail

Endorphins--a role in lower urinary tract function? The effect of opioid blockade on the detrusor and urethral sphincter mechanisms.
MedLine Citation:
PMID:  6758913     Owner:  NLM     Status:  MEDLINE    
A single blind trial of the effect of opioid blockade on lower urinary tract function, assessed urodynamically, is reported. Twenty patients (10 male, 10 female) were studied by filling and voiding cystometry and urethral pressure profilometry before and after the administration of a potent opioid antagonist, naloxone. A significant rise in subtracted detrusor pressure was demonstrated throughout bladder filling. Cystometric bladder capacity was reduced at both first and urgent desire to micturate. Significant reduction of the urethral closure pressure was also seen. These effects represent evidence of an endogenous opioid dependent element in the control of lower urinary tract function.
K H Murray; R C Feneley
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of urology     Volume:  54     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  638-40     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Endorphins / antagonists & inhibitors*
Middle Aged
Muscle, Smooth / drug effects,  physiology
Naloxone / pharmacology*
Urethra / drug effects*,  physiology
Urinary Bladder / drug effects*,  physiology
Reg. No./Substance:
0/Endorphins; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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