| Endorphins--a role in lower urinary tract function? The effect of opioid blockade on the detrusor and urethral sphincter mechanisms. | |
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MedLine Citation:
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PMID: 6758913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single blind trial of the effect of opioid blockade on lower urinary tract function, assessed urodynamically, is reported. Twenty patients (10 male, 10 female) were studied by filling and voiding cystometry and urethral pressure profilometry before and after the administration of a potent opioid antagonist, naloxone. A significant rise in subtracted detrusor pressure was demonstrated throughout bladder filling. Cystometric bladder capacity was reduced at both first and urgent desire to micturate. Significant reduction of the urethral closure pressure was also seen. These effects represent evidence of an endogenous opioid dependent element in the control of lower urinary tract function. |
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Authors:
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K H Murray; R C Feneley |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of urology Volume: 54 ISSN: 0007-1331 ISO Abbreviation: Br J Urol Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15740090R Medline TA: Br J Urol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 638-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clinical Trials as Topic Endorphins / antagonists & inhibitors* Female Humans Male Middle Aged Muscle, Smooth / drug effects, physiology Naloxone / pharmacology* Urethra / drug effects*, physiology Urinary Bladder / drug effects*, physiology Urodynamics |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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