| Endorphins and exercise: physiological mechanisms and clinical implications. | |
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MedLine Citation:
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PMID: 2205777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this paper we discuss recent experimental and clinical findings which lead us to propose that prolonged rhythmic exercise can activate central opioid systems by triggering increased discharge from mechanosensitive afferent nerve fibers (Group III or A-delta) arising from contracting skeletal muscle. We review evidence that supports the concept that many of the cardiovascular, analgesic, and behavioral effects of exercise are mediated by this mechanism and that the same or similar mechanisms are responsible for the central and peripheral effects of acupuncture. Based on this hypothesis, and supporting evidence from human and animal studies, we suggest a mechanism and a potential therapeutic role for exercise in the treatment of selected patients with disorders as diverse as hypertension, addiction, depression, and anorexia nervosa. |
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Authors:
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P Thorén; J S Floras; P Hoffmann; D R Seals |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 22 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-10-23 Completed Date: 1990-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 417-28 Citation Subset: IM; S |
Affiliation:
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Department of Physiology, University of Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acupuncture Therapy Anorexia Nervosa / physiopathology Blood Pressure / physiology Depressive Disorder / physiopathology Endorphins / physiology* Exercise / physiology* Exercise Therapy Humans Hypertension / physiopathology, therapy Models, Biological Muscle Contraction / physiology* Pain / physiopathology, therapy |
| Grant Support | |
ID/Acronym/Agency:
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AG00423/AG/NIA NIH HHS; AG06537/AG/NIA NIH HHS; HL39966/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endorphins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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