Document Detail

Endorphins and exercise: physiological mechanisms and clinical implications.
MedLine Citation:
PMID:  2205777     Owner:  NLM     Status:  MEDLINE    
In this paper we discuss recent experimental and clinical findings which lead us to propose that prolonged rhythmic exercise can activate central opioid systems by triggering increased discharge from mechanosensitive afferent nerve fibers (Group III or A-delta) arising from contracting skeletal muscle. We review evidence that supports the concept that many of the cardiovascular, analgesic, and behavioral effects of exercise are mediated by this mechanism and that the same or similar mechanisms are responsible for the central and peripheral effects of acupuncture. Based on this hypothesis, and supporting evidence from human and animal studies, we suggest a mechanism and a potential therapeutic role for exercise in the treatment of selected patients with disorders as diverse as hypertension, addiction, depression, and anorexia nervosa.
P Thorén; J S Floras; P Hoffmann; D R Seals
Related Documents :
20175637 - Promoting self-determined motivation for exercise in cardiac rehabilitation: the role o...
4037767 - Self-abatement of complex partial seizures.
9857497 - Predicting back pain sufferers' intentions to exercise.
19091807 - Using a website to build community and enhance outcomes in a group, multi-component int...
22089407 - "tap and twist": preventing deep vein thrombosis in neuroscience patients through foot ...
15785797 - The introduction of oxygen for pneumonia as seen through the writings of two mcgill uni...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  22     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-23     Completed Date:  1990-10-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  417-28     Citation Subset:  IM; S    
Department of Physiology, University of Göteborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acupuncture Therapy
Anorexia Nervosa / physiopathology
Blood Pressure / physiology
Depressive Disorder / physiopathology
Endorphins / physiology*
Exercise / physiology*
Exercise Therapy
Hypertension / physiopathology,  therapy
Models, Biological
Muscle Contraction / physiology*
Pain / physiopathology,  therapy
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enhanced demonstration of cell surface immunoglobulins in paraffin-processed tissue.
Next Document:  Initial events in exercise-induced muscular injury.