Document Detail

Endoretinal biopsy in establishing the diagnosis of uveitis: a clinicopathologic report of three cases.
MedLine Citation:
PMID:  15804774     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report the value of endoretinal biopsy in establishing the diagnosis of severe posterior uveitis. METHODS: A clinicopathologic report of three patients with severe posterior uveitis unresponsive to corticosteroids and with a negative systemic workup. These patients subsequently underwent vitrectomy and endoretinal biopsy. RESULTS: Endoretinal biopsy provided an accurate diagnosis in the three cases, leading to appropriate treatment. Histopathologic examination of the three retinal samples confirmed the diagnosis of sarcoidosis, tuberculosis, and lymphoma. Targeted treatment improved the ocular conditions in all three cases. CONCLUSIONS: In selected cases of severe bilateral vision-threatening uveitis, retinal biopsy may be indicated as a last resort to confirm a suspected diagnosis of infectious disease or malignancy.
Nathalie Cassoux; Fréderic Charlotte; Narsing A Rao; Bahram Bodaghi; Hélène Merle-Beral; Phuc Lehoang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  13     ISSN:  0927-3948     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Department of Ophthalmology, Pitié-Salpêtrière Hospital Paris France.
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MeSH Terms
Aged, 80 and over
Antitubercular Agents / therapeutic use
Glucocorticoids / therapeutic use
Lymphoma, B-Cell / diagnosis*,  surgery
Retina / pathology*
Sarcoidosis / diagnosis*,  drug therapy
Tuberculosis, Ocular / diagnosis*,  drug therapy
Uveitis, Posterior / diagnosis*
Reg. No./Substance:
0/Antitubercular Agents; 0/Glucocorticoids

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