Document Detail

Endoreplication and polyploidy: insights into development and disease.
MedLine Citation:
PMID:  23222436     Owner:  NLM     Status:  MEDLINE    
Polyploid cells have genomes that contain multiples of the typical diploid chromosome number and are found in many different organisms. Studies in a variety of animal and plant developmental systems have revealed evolutionarily conserved mechanisms that control the generation of polyploidy and have recently begun to provide clues to its physiological function. These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer.
Donald T Fox; Robert J Duronio
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  140     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-01-30     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-12     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / genetics,  physiology*
Endoreduplication / genetics,  physiology*
Genomic Instability / genetics,  physiology
Neoplasms / etiology,  genetics,  pathology*
Plants / anatomy & histology,  genetics

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