Document Detail


Endoreplication controls cell fate maintenance.
MedLine Citation:
PMID:  20585618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell-fate specification is typically thought to precede and determine cell-cycle regulation during differentiation. Here we show that endoreplication, also known as endoreduplication, a specialized cell-cycle variant often associated with cell differentiation but also frequently occurring in malignant cells, plays a role in maintaining cell fate. For our study we have used Arabidopsis trichomes as a model system and have manipulated endoreplication levels via mutants of cell-cycle regulators and overexpression of cell-cycle inhibitors under a trichome-specific promoter. Strikingly, a reduction of endoreplication resulted in reduced trichome numbers and caused trichomes to lose their identity. Live observations of young Arabidopsis leaves revealed that dedifferentiating trichomes re-entered mitosis and were re-integrated into the epidermal pavement-cell layer, acquiring the typical characteristics of the surrounding epidermal cells. Conversely, when we promoted endoreplication in glabrous patterning mutants, trichome fate could be restored, demonstrating that endoreplication is an important determinant of cell identity. Our data lead to a new model of cell-fate control and tissue integrity during development by revealing a cell-fate quality control system at the tissue level.
Authors:
Jonathan Bramsiepe; Katja Wester; Christina Weinl; Farshad Roodbarkelari; Remmy Kasili; John C Larkin; Martin Hülskamp; Arp Schnittger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-06-24
Journal Detail:
Title:  PLoS genetics     Volume:  6     ISSN:  1553-7404     ISO Abbreviation:  PLoS Genet.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-09-27     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101239074     Medline TA:  PLoS Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1000996     Citation Subset:  IM    
Affiliation:
Institut de Biologie Moléculaire des Plantes du CNRS, Université de Strasbourg, Strasbourg, France.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / cytology*,  genetics*,  growth & development
Cell Cycle*
Cell Differentiation
DNA Replication*
Microscopy, Electron, Scanning
Models, Genetic
Mutation
Comments/Corrections

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