| Endorectal and dynamic contrast-enhanced MRI for detection of local recurrence after radical prostatectomy. | |
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MedLine Citation:
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PMID: 18430830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of our study was to evaluate the sensitivity and specificity of endorectal MRI combined with dynamic contrast-enhanced MRI to detect local recurrence after radical prostatectomy. MATERIALS AND METHODS: A total of 51 patients who had undergone radical prostatectomy for prostatic adenocarcinoma 10 months to 6 years before underwent a combined endorectal coil MRI and dynamic gadolinium-enhanced MRI before endorectal sonographically guided biopsy of the prostatic fossa. The MRI combined with MR dynamic imaging results were correlated with the presence of recurrence defined as a positive biopsy result or reduction in prostate-specific antigen level after radiation therapy. RESULTS: Overall data of 46 (25 recurred, 21 nonrecurred) out of 51 evaluated patients were analyzed. All recurrences showed signal enhancement after gadolinium administration and, in particular, 22 of 24 patients (91%) showed rapid and early signal enhancement. The overall sensitivity and specificity of MR dynamic imaging was higher compared with MRI alone (88%, [95% CI] 69-98% and 100%, 84-100% compared with 48%, 28-69% and 52%, 30-74%). MRI combined with dynamic imaging allowed better identification of recurrences compared with MRI alone (McNemar test: chi-square(1) = 16.67; p = < 0.0001). CONCLUSION: MRI combined with dynamic contrast-enhanced MRI showed a higher sensitivity and specificity compared with MRI alone in detecting local recurrences after radical prostatectomy. |
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Authors:
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Emanuele Casciani; Elisabetta Polettini; Enrico Carmenini; Irene Floriani; Gabriele Masselli; Luca Bertini; Gian Franco Gualdi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 190 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-23 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 1187-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Rome La Sapienza, Via del Policlinico, 155, 00166 Rome, Italy. emanuelecasciani@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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pathology*,
surgery Aged Cohort Studies Contrast Media Gadolinium DTPA / diagnostic use Humans Magnetic Resonance Imaging* / methods Male Middle Aged Neoplasm Recurrence, Local / pathology* Predictive Value of Tests Prostatectomy* Prostatic Neoplasms / pathology*, surgery Reproducibility of Results Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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