Document Detail


Endoplasmic reticulum stress and pancreatic β-cell death.
MedLine Citation:
PMID:  21458293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment for insulin biosynthesis, which accounts for half of the total protein production in these cells. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR), which influences both life and death decisions in cells. β-cell loss is a pathological component of both type 1 and type 2 diabetes, and recent findings suggest that ER stress is involved. In this review, we address the transition from the physiological ER stress response to the pathological response, and explore the mechanisms of ER stress-mediated β-cell loss during the progression of diabetes.
Authors:
Sonya G Fonseca; Jesper Gromada; Fumihiko Urano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-03-31
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  22     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-05     Completed Date:  2011-11-08     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Death
Diabetes Mellitus / drug therapy,  metabolism,  prevention & control
Disease Progression
Endoplasmic Reticulum / metabolism*
Humans
Insulin-Secreting Cells / metabolism*
Molecular Targeted Therapy
Oxidative Stress
Protein Biosynthesis
Stress, Physiological*
Unfolded Protein Response
Grant Support
ID/Acronym/Agency:
5 P30 DK32520/DK/NIDDK NIH HHS; R01 DK067493/DK/NIDDK NIH HHS; R01 DK067493-06A1/DK/NIDDK NIH HHS; R01 DK067493-07/DK/NIDDK NIH HHS; R01DK067493/DK/NIDDK NIH HHS
Comments/Corrections

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