| Endoplasmic reticulum stress in beta cells: latent mechanism of secondary sulfonylurea failure in type 2 diabetes? | |
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MedLine Citation:
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PMID: 18786775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sulfonylureas, by stimulating beta cell to secrete insulin, are still largely used for treatment of type 2 diabetic patients. More recently concern has been raised with respect to possible adverse effects associated with the use of these agents, like favoring beta cell apoptosis and beta cell exhaustion, which is believed as the reason for high rate secondary sulfonylurea failure. Endoplasmic reticulum (ER) stress often occurred when load of client protein exceed the folding capacity in secretory cell. Here, we hypothesize that overstimulation by chronic use of sulfonylureas could probably leads to ER stress and finally apoptosis in beta cell, which might be the latent mechanism for secondary sulfonylurea failure. |
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Authors:
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Lei Qian; Suhe Zhang; Lihong Xu; Yongde Peng |
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Publication Detail:
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Type: Journal Article Date: 2008-09-10 |
Journal Detail:
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Title: Medical hypotheses Volume: 71 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-01 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 889-91 Citation Subset: IM |
Affiliation:
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Department of Endocrine and Metabolic Disease, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects Diabetes Mellitus, Type 2 / drug therapy*, physiopathology Endoplasmic Reticulum / physiology* Humans Hypoglycemic Agents / therapeutic use Insulin-Secreting Cells / drug effects, physiology* Models, Biological Sulfonylurea Compounds / therapeutic use* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Sulfonylurea Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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