Document Detail

Endoplasmic reticulum stress in beta cells: latent mechanism of secondary sulfonylurea failure in type 2 diabetes?
MedLine Citation:
PMID:  18786775     Owner:  NLM     Status:  MEDLINE    
Sulfonylureas, by stimulating beta cell to secrete insulin, are still largely used for treatment of type 2 diabetic patients. More recently concern has been raised with respect to possible adverse effects associated with the use of these agents, like favoring beta cell apoptosis and beta cell exhaustion, which is believed as the reason for high rate secondary sulfonylurea failure. Endoplasmic reticulum (ER) stress often occurred when load of client protein exceed the folding capacity in secretory cell. Here, we hypothesize that overstimulation by chronic use of sulfonylureas could probably leads to ER stress and finally apoptosis in beta cell, which might be the latent mechanism for secondary sulfonylurea failure.
Lei Qian; Suhe Zhang; Lihong Xu; Yongde Peng
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Publication Detail:
Type:  Journal Article     Date:  2008-09-10
Journal Detail:
Title:  Medical hypotheses     Volume:  71     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-01     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  889-91     Citation Subset:  IM    
Department of Endocrine and Metabolic Disease, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
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MeSH Terms
Apoptosis / drug effects
Diabetes Mellitus, Type 2 / drug therapy*,  physiopathology
Endoplasmic Reticulum / physiology*
Hypoglycemic Agents / therapeutic use
Insulin-Secreting Cells / drug effects,  physiology*
Models, Biological
Sulfonylurea Compounds / therapeutic use*
Treatment Failure
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Sulfonylurea Compounds

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