Document Detail


Endoplasmic reticulum stress and hypertension - a new paradigm?
MedLine Citation:
PMID:  23064369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension occurs in approximately 30% of individuals in Western populations and is known to be a major cause of stroke, heart failure, and myocardial infarction. Despite this, the molecular etiology of hypertension remains poorly understood. In this issue of the JCI, Young et al. show that endoplasmic reticulum (ER) stress is an essential signaling event for angiotensin II-induced hypertension in cells of the central nervous system. This provides new insight into the molecular mechanisms that drive hypertension and suggests a potential target for future therapy.
Authors:
Alyssa H Hasty; David G Harrison
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-15
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-01-15     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3859-61     Citation Subset:  AIM; IM    
Affiliation:
Department of Molecular Physiology and Biophysics and Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602, USA.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / adverse effects*
Animals
Brain / metabolism*
Endoplasmic Reticulum Stress*
Hypertension / metabolism*
Vasoconstrictor Agents / adverse effects*
Grant Support
ID/Acronym/Agency:
P01 GM015431/GM/NIGMS NIH HHS; P01 HL058000/HL/NHLBI NIH HHS; P01 HL095070/HL/NHLBI NIH HHS; P01GM015431/GM/NIGMS NIH HHS; P01HL058000/HL/NHLBI NIH HHS; P01HL095070/HL/NHLBI NIH HHS; R01 HL039006/HL/NHLBI NIH HHS; R01 HL105294/HL/NHLBI NIH HHS; R01HL039006/HL/NHLBI NIH HHS; R01HL089466/HL/NHLBI NIH HHS; R01HL105294-02/HL/NHLBI NIH HHS; R21DK95456/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II
Comments/Corrections
Comment On:
J Clin Invest. 2012 Nov 1;122(11):3960-4   [PMID:  23064361 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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