Document Detail


Endoplasmic reticulum stress enters a nogo zone.
MedLine Citation:
PMID:  21697529     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The debilitating disease pulmonary arterial hypertension (PAH) is characterized by an elevation in blood pressure in the lung arteries caused by vessel-blocking vascular-cell proliferation. This vascular remodeling is thought to result in part from defects in the endoplasmic reticulum stress response and mitochondrial dysfunction in pulmonary artery smooth muscle cells. In this issue of Science Translational Medicine, Sutendra et al. show that the vascular remodeling protein Nogo-B plays a role in the development of PAH in response to hypoxia-induced stress. The new findings finger Nogo-B as a possible therapeutic target for PAH.
Authors:
Juan Pablo Muñoz; Antonio Zorzano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science translational medicine     Volume:  3     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88ps26     Citation Subset:  IM    
Affiliation:
Institute for Research in Biomedicine (IRB Barcelona) C/Baldiri Reixac 10, 08028 Barcelona, Spain.
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