| Endoplasmic reticulum stress enters a nogo zone. | |
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MedLine Citation:
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PMID: 21697529 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The debilitating disease pulmonary arterial hypertension (PAH) is characterized by an elevation in blood pressure in the lung arteries caused by vessel-blocking vascular-cell proliferation. This vascular remodeling is thought to result in part from defects in the endoplasmic reticulum stress response and mitochondrial dysfunction in pulmonary artery smooth muscle cells. In this issue of Science Translational Medicine, Sutendra et al. show that the vascular remodeling protein Nogo-B plays a role in the development of PAH in response to hypoxia-induced stress. The new findings finger Nogo-B as a possible therapeutic target for PAH. |
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Authors:
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Juan Pablo Muñoz; Antonio Zorzano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science translational medicine Volume: 3 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
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Languages: eng Pagination: 88ps26 Citation Subset: IM |
Affiliation:
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Institute for Research in Biomedicine (IRB Barcelona) C/Baldiri Reixac 10, 08028 Barcelona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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