Document Detail

Endoplasmic reticulum stress enters a nogo zone.
MedLine Citation:
PMID:  21697529     Owner:  NLM     Status:  In-Data-Review    
The debilitating disease pulmonary arterial hypertension (PAH) is characterized by an elevation in blood pressure in the lung arteries caused by vessel-blocking vascular-cell proliferation. This vascular remodeling is thought to result in part from defects in the endoplasmic reticulum stress response and mitochondrial dysfunction in pulmonary artery smooth muscle cells. In this issue of Science Translational Medicine, Sutendra et al. show that the vascular remodeling protein Nogo-B plays a role in the development of PAH in response to hypoxia-induced stress. The new findings finger Nogo-B as a possible therapeutic target for PAH.
Juan Pablo Muñoz; Antonio Zorzano
Related Documents :
14508369 - Gadolinium-enhanced three-dimensional magnetic resonance angiography versus conventiona...
19452029 - Computed tomographic angiography as an adjunct to digital subtraction angiography for t...
18196229 - Three-dimensional time-of-flight mr angiography at 3 t compared to digital subtraction ...
12664119 - Preoperative evaluation of living renal donors: value of contrast-enhanced 3d magnetic ...
20609879 - Ct angiography of the lower extremities.
12098569 - Standardized mr protocol for the evaluation of mra sequences and/or contrast agents eff...
4042729 - The site and mechanism of oxygen sensing for the pulmonary vessels.
7153889 - Arterial and venous blood sampling in pharmacokinetic studies: griseofulvin.
11486219 - Technique of pulmonary autograft aortic valve replacement in children (the ross procedu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science translational medicine     Volume:  3     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88ps26     Citation Subset:  IM    
Institute for Research in Biomedicine (IRB Barcelona) C/Baldiri Reixac 10, 08028 Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Broken barriers: a new take on sepsis pathogenesis.
Next Document:  Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.