Document Detail

Endophthalmitis following open-globe injuries.
MedLine Citation:
PMID:  22134598     Owner:  NLM     Status:  MEDLINE    
The incidence of traumatic endophthalmitis may be decreasing due to earlier wound closure and prompt initiation of antibiotics. Risk factors for endophthalmitis include retained intraocular foreign body, rural setting of injury, disruption of the crystalline lens, and a delay in primary wound closure. The microbiology in the post-traumatic setting includes a higher frequency of virulent organisms such as Bacillus species. Recognizing early clinical signs of endophthalmitis, including pain, hypopyon, vitritis, or retinal periphlebitis may prompt early treatment with intravitreal antibiotics. Prophylaxis of endophthalmitis in high-risk open-globe injuries may include systemic broad-spectrum antibiotics, topical antibiotics, and intravitreal antibiotics to cover both Gram-positive and Gram-negative bacteria. For clinically diagnosed post-traumatic endophthalmitis, intravitreal vancomycin, and ceftazidime are routinely used. Concurrent retinal detachment with endophthalmitis can be successfully managed with vitrectomy and use of intravitreal antibiotics along with a long acting gas or silicone oil tamponade. Endophthalmitis is a visually significant complication of open-globe injuries but early wound closure as well as comprehensive prophylactic antibiotic treatment at the time of injury repair may improve visual acuity outcomes.
Y Ahmed; A M Schimel; A Pathengay; M H Colyer; H W Flynn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-02
Journal Detail:
Title:  Eye (London, England)     Volume:  26     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-03-28     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  212-7     Citation Subset:  IM    
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Endophthalmitis / diagnosis,  epidemiology,  etiology*,  prevention & control
Eye Foreign Bodies / complications,  surgery
Eye Injuries, Penetrating / complications*,  therapy
Retinal Detachment / complications*
Risk Factors
Visual Acuity
Grant Support
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
Eye (Lond). 2012 Sep;26(9):1277-8   [PMID:  22653518 ]

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