| Endophthalmitis following intravitreal injection versus endophthalmitis following cataract surgery: clinical features, causative organisms and post-treatment outcomes. | |
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MedLine Citation:
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PMID: 22446145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To describe and compare the causative organisms, clinical features and visual outcomes of endophthalmitis following intravitreal injection (IVI) to endophthalmitis following cataract surgery. METHODS: Patient population and setting: A retrospective case series of patients with acute endophthalmitis following either cataract surgery or IVI presenting to a tertiary referral centre--Sydney Eye Hospital--between 2007 and 2010. Main outcome measures: (1) identification of the causative organism; (2) time to presentation; (3) odds of improvement in visual acuity (VA) following treatment; (4) odds of final VA of counting fingers (CF) or less and (5) odds of enucleation. RESULTS: Of the 101 patients in our study, 48 had preceding cataract surgery and 53 had preceding IVI. There was an increased incidence of Streptococcus spp. endophthalmitis in post-IVI cases (24.53% vs 6.25%; OR 5.85; p=0.022). Endophthalmitis following IVI had increased likelihood of a final VA of CF or less (OR=6.0; p<0.01), decreased likelihood of any improvement in acuity following treatment (OR=0.13; p<0.01) and an increased likelihood of presenting within a week of the procedure (OR=3.93; p<0.01). Endophthalmitis caused by Streptococcus spp. was associated with increased likelihood of a final VA of CF or less (OR=10.2; p<0.01), decreased likelihood of any improvement in acuity following treatment (OR=0.06; p<0.01) and increased likelihood of enucleation (OR=17.11; p<0.01). CONCLUSIONS: Endophthalmitis following IVI is associated with an increased incidence of Streptococcus spp. infection, earlier presentation and poorer visual outcomes when compared with endophthalmitis following cataract surgery. |
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Authors:
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Matthew P Simunovic; Ryan B Rush; Alex P Hunyor; Andrew A Chang |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2012-03-24 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 96 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-16 Completed Date: 2012-07-19 Revised Date: 2012-11-20 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 862-6 Citation Subset: IM |
Affiliation:
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Sydney Eye Hospital, 8 Macquarie Street, Sydney, NSW 2000, Australia. mps23@cantab.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiogenesis Inhibitors / administration & dosage Anti-Bacterial Agents / therapeutic use Bacteria / isolation & purification* Cataract Extraction / adverse effects* Endophthalmitis* / diagnosis, microbiology, therapy Eye Enucleation Eye Infections, Bacterial* / diagnosis, microbiology, therapy Female Glucocorticoids / administration & dosage Humans Incidence Intravitreal Injections / adverse effects* Male Retrospective Studies Time Factors Visual Acuity / physiology Vitrectomy Vitreous Body / microbiology |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Anti-Bacterial Agents; 0/Glucocorticoids |
| Comments/Corrections | |
Comment In:
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Br J Ophthalmol. 2012 Oct;96(10):1349-50; author reply 1350
[PMID:
22679333
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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