Document Detail

Endomyocardial biopsy in hemochromatosis: clinicopathologic correlates in six cases.
MedLine Citation:
PMID:  2909558     Owner:  NLM     Status:  MEDLINE    
Clinical and pathologic features of cardiac hemochromatosis diagnosed by endomyocardial biopsy in six men, aged 32 to 75 years (mean 52), are described. Echocardiography demonstrated left ventricular enlargement and marked global systolic dysfunction in five. Cardiac catheterization demonstrated normal coronary arteries, increased left ventricular end-diastolic pressure and decreased left ventricular systolic function in all five so studied. Stainable iron was present in all endomyocardial biopsy specimens from the five patients with decreased left ventricular systolic function. Histologically, iron was detected only within the sarcoplasm, and its extent varied inversely with ventricular function. Thus, cardiac hemochromatosis represents a storage rather than an infiltrative disease. These results indicate that stainable iron is consistently observed in endomyocardial biopsy specimens from patients with impaired left ventricular systolic function. Iron staining is recommended for endomyocardial biopsy specimens from patients with idiopathic cardiac dysfunction.
L J Olson; W D Edwards; D R Holmes; F A Miller; L A Nordstrom; W P Baldus
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  13     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  AIM; IM    
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Dyspnea / etiology
Endocardium / pathology*
Heart Catheterization
Heart Failure / etiology
Hemochromatosis / complications,  mortality,  pathology*
Liver / pathology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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