Document Detail

Endomyocardial biopsy findings in 50 patients with idiopathic atrioventricular block: presence of myocarditis.
MedLine Citation:
PMID:  11933919     Owner:  NLM     Status:  MEDLINE    
In patients with primary atrioventricular (AV) conduction disturbances, lesions are commonly believed to be limited to the conduction system. In the present study, myocardial lesions were analyzed histologically in patients with AV conduction disturbances to determine the presence of myocarditis. We studied 50 patients with second or third degree AV block in whom the cause was not clear (AVB group). Endomyocardial biopsy was performed from the right ventricle and examined by light microscopy. Tissue specimens also were obtained from 12 normal hearts at autopsy as a control group (N group). The diagnosis of myocarditis was based on the Dallas criteria. The myocyte transverse diameter was 15.4+/-4.1 microm in the AVB group and 11.7+/-3.1 microm in the N group (P<0.01). The fibrosis area ratio also was significantly higher in the AVB group than in the N group (10.1+/-6.7% vs 5.1+/-2.0%). The mean number of lymphocytes per 400-fold magnified field was significantly greater in the AVB group than in the N group (1.9+/-1.6 vs 1.3+/-0.4). In addition, disorganization of the cardiac myocytes was noted in 8 patients in the AVB group (16%), myocyte disarrangement in 39 patients (78%), myocytolysis in 23 patients (46%), and nuclear deformity in 21 patients (42%). Myocarditis was diagnosed in 3 of the 50 patients (6%). The present study demonstrates that myocardial lesions can be detected in a large proportion of patients with AV conduction disturbances. Furthermore, myocarditis is present in 6% of the cases.
A Uemura; S Morimoto; S Hiramitsu; H Hishida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  42     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-04-05     Completed Date:  2002-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  691-700     Citation Subset:  IM    
Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
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MeSH Terms
Aged, 80 and over
Cardiomegaly / pathology
Endocardium / pathology*
Heart Block / etiology,  pathology*,  physiopathology
Heart Conduction System / physiopathology
Heart Ventricles / pathology
Lymphocyte Count
Middle Aged
Myocarditis / complications,  pathology*
Myocardium / pathology*

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