Document Detail


Endomyocardial biopsy approach to patients with ventricular tachycardia with special reference to arrhythmogenic right ventricular dysplasia.
MedLine Citation:
PMID:  3599366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Right ventricular endomyocardial biopsies were performed in patients with repetitive ventricular tachycardia (VT; 8 patients) or ventricular premature beats (1 patient) which showed left bundle branch block morphology in electrocardiograms. These 9 male patients ranging in age from 21-55 years (mean 37.7 years) revealed enlargement and/or asynergy of the right ventricle in the ventriculogram. Randomly selected biopsied patients with dilated cardiomyopathy (DCM; 18 patients) and chronic right ventricular overloading (14 patients) who did not show the above-described arrhythmias served as controls. A histopathological analysis revealed advanced myocardial interstitial fibrosis associated with an increase in fatty tissue in 8 of the 9 patients (89%). Moreover, advanced hypertrophy of myocytes (grade 2 or more of our criteria), disarrangement of muscle bundles and endocardial thickening were prominent with incidences of 75%, 75% and 78%, respectively. Incidence of all findings was more pronounced in the ARVD group. Suggestiveness of post-myocarditic change in the biopsied specimen was high in 1 patient, showing a lower incidence (12%) than the DCM group (17%). From these results, we can conclude that different etiological factors may be the bases of these pathological changes. We believe that the presence of a large amount of fatty tissue within the myocardial tissue is an important element in the etiology of ventricular arrhythmias as it has also been recognized in patients with non-ARVD idiopathic ventricular tachycardia in our biopsy series.
Authors:
M Hasumi; M Sekiguchi; M Hiroe; H Kasanuki; K Hirosawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  51     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-08-04     Completed Date:  1987-08-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  242-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiomyopathies / pathology*,  physiopathology
Hemodynamics
Humans
Male
Middle Aged
Tachycardia / pathology*,  physiopathology

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