| Endomorphin 1 and 2, endogenous mu-opioid agonists, decrease systemic arterial pressure in the rat. | |
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MedLine Citation:
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PMID: 9519803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endogenous opioid peptides, endomorphin 1 and 2, are newly isolated, potent, and selective mu-opioid receptor agonists. In the present study, responses to endomorphin 1 and 2 were investigated in the systemic vascular bed of the rat. Endomorphin 1 and 2 induced dose-related decreases in systemic arterial pressure when injected in doses of 1-30 nmol/kg i.v. In terms of relative vasodepressor activity, endomorphin 1 and 2 were approximately equipotent with each other and with the ORL1 ligand, nociceptin (orphanin FQ), and were about 10-fold more potent than met-enkephalin in decreasing systemic arterial pressure. Vasodepressor responses to endomorphin 1 and 2 and met-enkephalin, but not to nociceptin, were inhibited by the opioid receptor antagonist, naloxone. These results demonstrate that endomorphin 1 and 2 produce significant naloxone-sensitive decreases in systemic arterial pressure. |
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Authors:
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M A Czapla; H C Champion; J E Zadina; A J Kastin; L Hackler; L J Ge; P J Kadowitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 62 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-04-06 Completed Date: 1998-04-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: PL175-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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pharmacokinetics,
pharmacology* Animals Blood Pressure / drug effects* Enkephalin, Methionine / pharmacology Female Male Oligopeptides / pharmacokinetics, pharmacology* Opioid Peptides / pharmacology Rats Rats, Sprague-Dawley Receptors, Opioid, mu / agonists* Vasoconstrictor Agents / pharmacokinetics, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Oligopeptides; 0/Opioid Peptides; 0/Receptors, Opioid, mu; 0/Vasoconstrictor Agents; 0/endomorphin 1; 0/endomorphin 2; 0/nociceptin; 58569-55-4/Enkephalin, Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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