Document Detail

Endometriosis: the way forward.
MedLine Citation:
PMID:  17484506     Owner:  NLM     Status:  MEDLINE    
Endometriosis, a common cause of morbidity, affects 10% of women of reproductive age. In this review we focus on the new developments in pathogenesis, diagnosis and treatment options, reviewing the literature published about this enigmatic disorder over the past three years. More specifically, new theories of the pathogenesis of the syndrome of Sampson and Cullen are discussed. The new era of genomics may characterize endometriosis and transform clinical management of the disease. Literature suggesting that endometriosis may have an environmental origin is reviewed. New approaches to medical therapy of endometriosis have been developed, including the levonorgestrel-releasing intrauterine device, aromatase inhibitors, immunomodulatory drugs, angiogenesis inhibitors, selective estrogen and progesterone receptor modulators, and statins. Subfertility is another well-known result of endometriosis and often complex decisions must be made regarding management of the endometriosis patient who wishes to conceive. Laparoscopic surgery and assisted reproduction--with or without gonadotropin-releasing hormone-agonist treatment--are reviewed. Finally we speculate about new developments in the field of endometriosis in the coming three years.
Peter G A Hompes; Velja Mijatovic
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  23     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-05-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-12     Citation Subset:  IM    
Division of Reproductive Medicine, Department of Obstetrics & Gynecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands.
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MeSH Terms
Acyl Coenzyme A / administration & dosage
Angiogenesis Inhibitors / administration & dosage
Aromatase Inhibitors / administration & dosage
Endometriosis / diagnosis*,  therapy*
Immunologic Factors / administration & dosage
Levonorgestrel / administration & dosage
Selective Estrogen Receptor Modulators / administration & dosage
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Angiogenesis Inhibitors; 0/Aromatase Inhibitors; 0/Immunologic Factors; 0/Selective Estrogen Receptor Modulators; 1553-55-5/3-hydroxy-3-methylglutaryl-coenzyme A; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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