Document Detail


Endometriosis-associated infertility: surgery and IVF, a comprehensive therapeutic approach.
MedLine Citation:
PMID:  20541976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infertility is a common problem presented by patients with endometriosis. At present, whichever treatment is chosen, half of patients with advanced stages of the disease will remain infertile afterwards. This observational study looked at the reproductive outcome achieved after treating a group of 825 patients aged between 20 and 40 years with endometriosis-associated infertility during the period 2001-2008. Of the 483 patients who had surgery as the primary option, 262 became pregnant (54.2%). Among the patients who did not become pregnant, 144 underwent 184 IVF cycles and 56 additional pregnancies were obtained (30.4% clinical pregnancy rate per retrieval). It is notable that, before any treatment, patients with endometriosis had a poorer ovarian reserve than the control group. The combined strategy of endoscopic surgery and subsequent IVF led to a total of 318 pregnancies, which represents a combined clinical pregnancy rate of 65.8%. This percentage is significantly higher than that obtained with surgery alone (P < 0.0001), with 173 patients who were not operated on and who went to IVF as the primary option (P < 0.0001) and with 169 patients who had no treatment and achieved 20 spontaneous pregnancies (P < 0.0001).
Authors:
Pedro N Barri; Buenaventura Coroleu; Rosa Tur; Pedro N Barri-Soldevila; Ignacio Rodríguez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-27
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  21     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  IM    
Copyright Information:
2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproduction, Institut Universitari Dexeus, Gran Via Carles III 71-75, 08028 Barcelona, Spain. pbarri@dexeus.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Endometriosis / complications*
Female
Fertilization in Vitro*
Humans
Infertility, Female / complications*,  physiopathology,  surgery
Pregnancy
Pregnancy Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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