| Endometrial vascularization in levonorgestrel intrauterine device users; computerized microvessel measurement study. | |
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MedLine Citation:
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PMID: 15639075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Levonorgestrel use in the levonorgestrel intrauterine device (LNG-IUS) induces vascular distension within the superficial layer of the endometrium and massive pseudodecidualization. With a computer-assisted image analysis system, we objectively measured the vascular bed in LNG-IUS users and compared it to the physiological endometrium. A study was undertaken on 25 women using LNG-IUS, in an outpatient procedure at the time of removal of the IUS and compared with 11 normally cycling women (control group). Suction curette specimens were obtained just after retrieval of the IUS, and immunohistochemistry was carried out with a specific marker of the endothelial cells (CD31). Number of vessels decreased in the LNG-IUS group to 60/mm2 versus 124/mm2 in the control group, and mean vessel area increased to 1255 microm2 versus 157 microm2, respectively, in the control group. The decrease in mean vascular density and the increase of mean vessel area in the LNG-IUS group, compared to the control group, were both highly significant (p<.001). |
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Authors:
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Michel Jondet; Bernard Letellier; Marie-Thérèse Verdys |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Contraception Volume: 71 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-10 Completed Date: 2005-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 60-4 Citation Subset: IM |
Affiliation:
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Cabinet d'Anatomie et de Cytologie Pathologiques, 34 rue Ducouédic, 75014 Paris, France. mjondet@free.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Endometrium / blood supply*, drug effects* Female Humans Image Processing, Computer-Assisted Immunohistochemistry Intrauterine Devices, Medicated* Levonorgestrel / pharmacology* Microcirculation / drug effects Neovascularization, Physiologic / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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797-63-7/Levonorgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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