Document Detail

Endometrial thickness predicts intrauterine pregnancy in patients with pregnancy of unknown location.
MedLine Citation:
PMID:  19035545     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether endometrial thickness and other parameters are useful predictors of normal intrauterine pregnancy (IUP) in the setting of vaginal bleeding and sonographic diagnosis of pregnancy of unknown location (PUL). METHODS: We reviewed the clinical and sonographic records of all 591 patients with vaginal bleeding and a sonographic diagnosis of PUL between 1 July 2005 and 30 June 2006. Data on maternal age, gravidity, parity, estimated gestational age by last menstrual period (EGA by LMP), endometrial thickness and serum beta-human chorionic gonadotropin (beta-hCG) were collected. Complete data were available for 517 patients, 40 (7.7%) of whom ultimately had normal IUPs. A logistic regression model was constructed using a stepwise procedure to identify variables significantly associated with the outcome of normal IUP. The validity of the model was assessed by receiver-operating characteristics (ROC) curve and Hosmer-Lemeshow Chi-square analysis. RESULTS: Four variables (maternal age, EGA by LMP, endometrial thickness and serum beta-hCG) were significant in the prediction of normal IUP (area under the ROC curve = 0.86). As maternal age, EGA by LMP and beta-hCG increased, the likelihood of a normal IUP decreased, while as the endometrial thickness increased, the likelihood of a normal IUP increased. For each millimeter increase in endometrial thickness, the odds increased by 27% that the patient would have a normal IUP. No normal IUP had an endometrial thickness < 8 mm. CONCLUSION: Increased endometrial thickness predicts normal IUP in patients who present with vaginal bleeding and PUL.
E Moschos; D M Twickler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  32     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-02     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  929-34     Citation Subset:  IM    
Copyright Information:
(c) 2008 ISUOG.
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood*
Endometrium / ultrasonography*
Logistic Models
Maternal Age
Models, Biological
Predictive Value of Tests
Pregnancy, Ectopic / blood,  diagnosis*,  ultrasonography
ROC Curve
Retrospective Studies
Ultrasonography, Prenatal
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human

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