Document Detail

Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders.
MedLine Citation:
PMID:  15016770     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Impaired implantation in assisted reproduction cycles with high serum estradiol (E(2)) concentrations may be related to suboptimal endometrial perfusion. Endometrial and subendometrial blood flow were compared between excessive responders (serum E(2) on the day of HCG >20 000 pmol/l) and moderate responders (E(2) < or =20 000 pmol/l). METHODS: Three-dimensional (3D) ultrasound examination with power Doppler was performed 2, 4 and 7 days after HCG in 32 patients who did not have embryo transfer in order to measure endometrial thickness, pulsatility index (PI)/resistance index (RI) of uterine vessels, and endometrial volume, vascularization index (VI)/flow index (FI)/vascularization flow index (VFI) of endometrial and subendometrial regions. RESULTS: Excessive responders tended to have lower endometrial and subendometrial VI/VFI on HCG +2 and more absent endometrial/subendometrial blood flow. They had significantly higher endometrial FI and subendometrial VFI than moderate responders on HCG +7. Only in the excessive responder group, uterine PI/RI declined significantly from HCG +2 to HCG +7 and endometrial VI/VFI increased significantly from HCG +4 to HCG +7. CONCLUSION: Changes in uterine Doppler flow indices, and endometrial and subendometrial 3D power Doppler flow indices during the early luteal phase were significantly different between moderate and excessive responders.
Ernest Hung Yu Ng; Carina Chi Wai Chan; Oi Shan Tang; William Shu Biu Yeung; Pak Chung Ho
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-03-11
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  19     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-22     Completed Date:  2004-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  924-31     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The University of Hong Kong, 6/F, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China.
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MeSH Terms
Blood Vessels / ultrasonography
Chorionic Gonadotropin / therapeutic use*
Endometrium / blood supply*,  ultrasonography*
Estradiol / blood*
Imaging, Three-Dimensional
Infertility, Female / physiopathology*,  ultrasonography*
Luteal Phase*
Pulsatile Flow
Regional Blood Flow
Ultrasonography, Doppler
Vascular Resistance
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol

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