Document Detail


Endometrial stromal sarcoma: experience from a district hospital and literature review.
MedLine Citation:
PMID:  20099500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Endometrial stromal sarcoma (ESS) is a rare malignancy of the uterus. Most cases are incidentally diagnosed on histological examination of hysterectomy specimens. Evidence on the management is accrued mainly from retrospective studies. This study aims to review the clinical experience of a district hospital in the diagnosis and management of this rare tumour over a 12-year period. METHODS: Information on cases of ESS from 1995 to 2007 were retrieved from the histological database. All case files of identified patients were analysed and data extrapolated. A literature review was performed. RESULTS: There were seven cases identified over this time period highlighting the rarity of ESS. Most cases were low-grade ESS and diagnosed retrospectively following surgery for presumed benign pathology. Cases with high-grade ESS and advanced stage low-grade ESS received adjuvant therapy. CONCLUSION: The primary treatment of ESS is surgery. The role of adjuvant therapy remains debatable, but generally involves radiotherapy, chemotherapy and hormonal therapy Optimal treatment protocols may be achieved by the conduct of randomised controlled clinical trials.
Authors:
G Somoye; H Lawton; S Havenga
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  30     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  664-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, The Queen Elizabeth Hospital, Norfolk, UK. g.somoye@nhs.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents, Hormonal / therapeutic use
Chemotherapy, Adjuvant
Endometrial Neoplasms / drug therapy,  pathology*,  surgery
Female
Great Britain
Hospitals, District*
Humans
Lymph Node Excision
Middle Aged
Retrospective Studies
Sarcoma, Endometrial Stromal / drug therapy,  pathology*,  surgery
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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