Document Detail


Endometrial progesterone and estradiol receptors in patients with recurrent early pregnancy loss of unknown etiology--preliminary report.
MedLine Citation:
PMID:  11208405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: It is not possible to identify the cause of the recurrent early pregnancy loss in approximately half of the cases, and different results have been reported according to estrogen (ER) and progesterone receptors (PR). The objective of this work was to evaluate the PR and ER levels in the endometrium of patients with recurrent early pregnancy loss, and to compare them with those of patients with proven fertility. MATERIAL AND METHODS: Endometrial receptors (R) for estrogen and progesterone as well as estradiol (E2) and progesterone (P) levels were determined in patients with recurrent early pregnancy loss, and compared with patients with proven fertility. RESULTS: The E2 and P levels, and the E2/P ratio did not show significant differences among the groups. Estrogen receptor in the cytoplasm and nucleus was lower in those with miscarriages, but without significant differences between the groups. However, the cytoplasmic PR was lower in those with pregnancy loss (p < 0.04), while nuclear PR was lower in the control group (p < 0.04). CONCLUSION: Maybe low PR levels can be the cause of early pregnancy loss of unknown etiology, but this deserves further investigation.
Authors:
S Carranza-Lira; J Blanquet; K Tserotas; L Calzada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  6     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2001-03-05     Completed Date:  2001-04-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  759-62     Citation Subset:  IM    
Affiliation:
Gynecologic Endocrinology Service, Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México DF. scarranzal@mexis.com
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / etiology,  metabolism*
Adult
Case-Control Studies
Cell Nucleus / metabolism
Cytoplasm / metabolism
Endometrium / metabolism*
Estradiol / metabolism
Female
Humans
Pregnancy
Progesterone / metabolism
Receptors, Estradiol / metabolism*
Receptors, Progesterone / metabolism*
Chemical
Reg. No./Substance:
0/Receptors, Estradiol; 0/Receptors, Progesterone; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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