Document Detail


Endometrial polyps affect uterine receptivity.
MedLine Citation:
PMID:  21269620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair implantation. These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps.
Authors:
Beth W Rackow; Elisa Jorgensen; Hugh S Taylor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-26
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-27     Completed Date:  2011-08-26     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2690-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Connecticut
Down-Regulation
Embryo Implantation* / genetics
Female
Fertility* / genetics
Genetic Markers
Homeodomain Proteins / genetics
Humans
Hysteroscopy
Infertility, Female / etiology*,  genetics,  physiopathology
Polyps / complications*,  genetics,  physiopathology
Pregnancy
Pregnancy Rate
RNA, Messenger / analysis
Uterine Diseases / complications*,  genetics,  physiopathology
Uterus / chemistry,  physiopathology*
Young Adult
Grant Support
ID/Acronym/Agency:
HD036887/HD/NICHD NIH HHS; HD052668/HD/NICHD NIH HHS; R01 HD036887/HD/NICHD NIH HHS; R01 HD036887-10/HD/NICHD NIH HHS; U54 HD052668/HD/NICHD NIH HHS; U54 HD052668-05/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/HOXA11 protein, human; 0/Homeodomain Proteins; 0/RNA, Messenger; 140441-81-2/HOXA10 protein, human
Comments/Corrections

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