Document Detail

Endometrial perfusion across the normal human menstrual cycle assessed by laser Doppler fluxmetry.
MedLine Citation:
PMID:  9043917     Owner:  NLM     Status:  MEDLINE    
This study investigated variations in microvascular perfusion of human endometrium across the menstrual cycle, using a laser Doppler technique to assess red blood cell (RBC) flux. Endometrial RBC flux was monitored by laser Doppler fluxmetry via a fibre optic probe inserted transvaginally into the uteri of 19 conscious normal volunteer women, on four occasions at weekly intervals over one menstrual cycle. Regional variation in RBC flux was investigated in 16 surgical patients under general anaesthesia and in five excised uteri. Endometrial perfusion exhibited short-term temporal variations consistent with the cardiac cycle and often also showed vasomotion (5-12 cycles/min). Mean endometrial perfusion differed between phases of the menstrual cycle in conscious women, being highest during early proliferative and early follicular phases. There were no significant regional differences in local mean endometrial perfusion in anaesthetized patients. No evidence of endometrial ischaemia/reperfusion episodes was found in any subject using this technique. This study provides benchmark data of variations in RBC flux per unit volume of tissue in the luminal approximately 1 mm of endometrium, across the normal human menstrual cycle. Flux values were highest at times associated with endometrial growth and preparation for implantation, indicating that RBC flux may be a useful parameter for assessment of endometrial physiology.
B J Gannon; C J Carati; C J Verco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  12     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-02     Completed Date:  1997-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  132-9     Citation Subset:  IM    
Department of Anatomy and Histology, School of Medicine, Flinders University, Adelaide, South Australia, Australia.
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MeSH Terms
Endometrium / blood supply*
Follicular Phase / physiology
Laser-Doppler Flowmetry*
Menstrual Cycle*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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