Document Detail

Endometrial hyperplasia in women on cyclic or continuous estrogen regimens.
MedLine Citation:
PMID:  6277698     Owner:  NLM     Status:  MEDLINE    
Twenty-five symptomatic postmenopausal women with an intact uterus were assigned in random double-blind fashion to receive 0.625 mg of conjugated estrogens on either a cyclic (3 weeks on, 1 week off) or continuous (daily) basis. The incidence of endometrial hyperplasia as demonstrated by screening biopsies at 6 and 12 months of therapy was 4.5 per 100 woman-months in the cyclic group and 3.7 per 100 woman-months in the continuous group (a difference not statistically significant). Thus, in this study, cyclic therapy was found to offer no advantage over continuous therapy. In our opinion, the rate of hyperplasia development in both groups unacceptably high, and efforts must be directed at reducing its incidence primarily.
I Schiff; H K Sela; D Cramer; D Tulchinsky; K J Ryan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  37     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Drug Administration Schedule*
Endometrial Hyperplasia / etiology*
Endometrium / pathology
Estrogens, Conjugated (USP) / administration & dosage*,  adverse effects
Menopause / drug effects*
Middle Aged
Reg. No./Substance:
0/Estrogens, Conjugated (USP)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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