| Endometrial hyperplasia in women on cyclic or continuous estrogen regimens. | |
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MedLine Citation:
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PMID: 6277698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-five symptomatic postmenopausal women with an intact uterus were assigned in random double-blind fashion to receive 0.625 mg of conjugated estrogens on either a cyclic (3 weeks on, 1 week off) or continuous (daily) basis. The incidence of endometrial hyperplasia as demonstrated by screening biopsies at 6 and 12 months of therapy was 4.5 per 100 woman-months in the cyclic group and 3.7 per 100 woman-months in the continuous group (a difference not statistically significant). Thus, in this study, cyclic therapy was found to offer no advantage over continuous therapy. In our opinion, the rate of hyperplasia development in both groups unacceptably high, and efforts must be directed at reducing its incidence primarily. |
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Authors:
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I Schiff; H K Sela; D Cramer; D Tulchinsky; K J Ryan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Fertility and sterility Volume: 37 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1982 Jan |
Date Detail:
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Created Date: 1982-05-12 Completed Date: 1982-05-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 79-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Clinical Trials as Topic Double-Blind Method Drug Administration Schedule* Endometrial Hyperplasia / etiology* Endometrium / pathology Estrogens, Conjugated (USP) / administration & dosage*, adverse effects Female Humans Menopause / drug effects* Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Estrogens, Conjugated (USP) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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