Document Detail

Endometrial histopathology, ovarian changes and bleeding patterns among users of long-acting progestin-only contraceptives in Egypt.
MedLine Citation:
PMID:  23113539     Owner:  NLM     Status:  Publisher    
Objective To evaluate endometrial and ovarian effects, and bleeding patterns, among users of Depo-Provera((®)), Norplant((®)), and Implanon((®)). Study design One-hundred and fifty women, who had been using one of these long-acting progestin-only contraceptives (LAPCs) for at least the previous six months, with fifty in each of the groups, were assessed. Results All results are mentioned in the following sequence: (1) Depo-Provera((®)), (2) Norplant((®)), and (3) Implanon((®)). Normal bleeding was reported by 0%, 52%, and 8%; amenorrhoea or infrequent bleeding by 68%, 24%, and 72%; and abnormal bleeding by 32%, 24%, and 20%, respectively (p < 0.001). Histological evaluation revealed an atrophic endometrium in 84%, 32%, and 28%, respectively (p < 0.0001); a progestin effect in 16%, 28%, and 62%, respectively (p < 0.0001), and a proliferative pattern in 0%, 40%, and 10%, respectively (p < 0.0001). Endometrial thickness was 3 ± 0.41 mm, 3.62 ± 0.65 mm, and 5.2 ± 0.84 mm, respectively (p < 0.0001). Follicular growth in the ovaries was observed at ultrasound in 12%, 40%, and 72%, respectively (p < 0.001). Conclusion Bleeding patterns, endometrial thickness, ovarian activity, and endometrial histology among Egyptian users of LAPCs differed significantly depending on the nature of the contraceptive.
Mohamed Laban; Magda Abd Alhamid; Eman A Ibrahim; Ali Elyan; Ahlam Ibrahim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-31
Journal Detail:
Title:  The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception     Volume:  -     ISSN:  1473-0782     ISO Abbreviation:  Eur J Contracept Reprod Health Care     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712127     Medline TA:  Eur J Contracept Reprod Health Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
* Department of Obstetrics & Gynaecology.
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