Document Detail

Endometrial glandular and stromal breakdown, part 1: cytomorphological appearance.
MedLine Citation:
PMID:  16900469     Owner:  NLM     Status:  MEDLINE    
Endometrial carcinoma is the most common invasive neoplasm of the female reproductive tract. Early detection and accurate diagnosis of these lesions and its precursor by endometrial cytology is now accepted in Japan and regarded as an effective primary method of evaluating endometrial pathology (atypical hyperplasia or carcinoma). Careful cytomorphologic evaluation of the abnormal endometrial lesions has made possible an accurate and reproducible microscopic assessment. The current study was conducted to determine the significance of endometrial cytology on disordered endometrium associated with anovulation when compared with endometrial hyperplasia. From January 1998 through April 2004, 144 cases on which histopathological diagnoses were obtained by endometrial curettage after taken direct endometrial sample by Endocyte. The materials comprise 49 cases of normal proliferative endometrium, and 63 cases of endometrial hyperplasia without atypia were prepared as control cases. The cytomorphology was examined involving so-called endometrial glandular and stromal breakdown (EGBD). EGBD cases evidenced significant numbers of stromal cells condensed and formed compact nests with hyperchromatic nuclei and little or no cytoplasm. They were often associated with fragmented clusters of endometrial glands with condensed cluster of stromal cells. Both the fragmented cluster of endometrial glands and condensed cluster of stromal cells are a characteristic cytologic feature of EGBD endometrium on the cyto-architectural diagnosis. The combination of these cellular patterns is highly specific to this abnormal pathological condition in EGBD endometrium. To improve the accuracy of the cytodiagnosis, it is important that the cytology of the EGBD endometrium should be diagnosed negative; as a result, we can achieve successful endometrial cytology with cyto-architectural criteria for the endometrial pathology.
Keiko Shimizu; Yoshiaki Norimatsu; Tadao K Kobayashi; Seiko Ogura; Yasuyuki Miyake; Eiji Ohno; Takaki Sakurai; Takuya Moriya; Masami Sakurai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  34     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2006-10-17     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  609-13     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Department of Pathology, Saiseikai Noe Hospital, Imperial Gift Foundation Inc., Osaka, Japan.
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MeSH Terms
Anovulation / complications,  pathology
Biopsy / methods*
Cell Nucleus / pathology
Cell Proliferation
Decidua / pathology*,  surgery
Endometrial Hyperplasia / complications,  pathology*,  surgery
Middle Aged
Stromal Cells / pathology
Uterine Hemorrhage / complications,  pathology,  surgery
Vaginal Smears / methods*

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