| Endolysosomal proteases and their inhibitors in immunity. | |
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MedLine Citation:
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PMID: 19935806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cellular endolysosomal compartment is dynamic, complex and incompletely understood. Its organelles and constituents vary between different cell types, but endolysosomal proteases are key components of this compartment in all cells. In immune cells, these proteases function in pathogen recognition and elimination, signal processing and cell homeostasis, and they are regulated by dedicated inhibitors. Pathogens can produce analogous proteases to subvert the host immune response. The balance in activity between a protease and its inhibitor can tune the immune response or cause damage as a result of mislocalized proteolysis. In this Review, we highlight recent developments in this area and emphasize the importance of studying the role of endolysosomal proteases, and their natural inhibitors, in the initiation and regulation of immune responses. |
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Authors:
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Phillip I Bird; Joseph A Trapani; Jos?? A Villadangos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 9 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 871-82 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia. Phil.Bird@med.monash.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen Presentation / immunology Antigen-Presenting Cells / enzymology, immunology Host-Pathogen Interactions / immunology Humans Lymphocytes / enzymology, immunology Lysosomes / enzymology*, immunology Peptide Hydrolases / immunology* Protease Inhibitors / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Protease Inhibitors; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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