| Endogenous testosterone and serum lipids in middle-aged men. | |
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MedLine Citation:
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PMID: 17588587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The role of decreasing testosterone levels influencing lipid metabolism in aging men is not well established. METHODS: We studied 1619 40 to 69-year old men with andropausal symptoms, who underwent measurements of serum testosterone, triglycerides, total-, and HDL-cholesterol. RESULTS: Testosterone (mean 15.25 nmol/l+/-5.43 S.D., range 3.6-45.0 nmol/l) correlated directly with HDL-cholesterol (r=0.24, p<0.0001) and inversely with total cholesterol (r=-0.06, p<0.03), triglycerides (r=-0.30, p<0.0001) and body mass index (r=-0.34, p<0.0001), but not with LDL-cholesterol (r=0.05, p=0.09). In multivariate analyses adjusted for age, body mass index, smoking, alcohol consumption, diabetes and cardiovascular diseases, the significant determinants for serum triglycerides were testosterone (beta=-0.03, p<0.0001), age (beta=-0.01, p<0.0001), body mass index (beta=0.039, p<0.0001) and cardiovascular diseases (beta=0.09, p<0.04). The multivariate correlates of HDL-cholesterol included testosterone (beta=0.007, p<0.0001), body mass index (beta=-0.02, p<0.0001) and alcohol consumption (beta=0.02, p<0.0001). CONCLUSIONS: We conclude that in aging men low testosterone levels are associated with a potentially atherogenic lipid profile including high triglycerides and low HDL-cholesterol. |
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Authors:
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Juuso I Mäkinen; Antti Perheentupa; Kerttu Irjala; Pasi Pöllänen; Juha Mäkinen; Ilpo Huhtaniemi; Olli T Raitakari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-22 |
Journal Detail:
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Title: Atherosclerosis Volume: 197 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 688-93 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, University of Turku, FIN-20520 Turku, Finland. juumak@utu.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / blood* Andropause / physiology* Cholesterol, HDL / blood* Cross-Sectional Studies Health Surveys Humans Hypertriglyceridemia Male Testosterone / blood* Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Triglycerides; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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