Document Detail


Endogenous soluble receptor for advanced glycation endproducts is increased in preeclampsia.
MedLine Citation:
PMID:  18698218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Preeclampsia is a serious complication in pregnancy with an increased future cardiovascular risk for both mother and newborn. Recently, low levels of endogenous soluble receptor for advanced glycation endproducts (esRAGE) have been associated with increased cardiovascular risk. In the current study, we investigated esRAGE serum levels in patients with preeclampsia as compared to healthy gestational age-matched controls.
METHODS: esRAGE was quantified by enzyme-linked immunosorbent assay in controls and patients with preeclampsia during pregnancy (control: n = 20, preeclampsia: n = 16) and 6 months after delivery (control: n = 19, preeclampsia: n = 15). Furthermore, esRAGE was correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation.
RESULTS: During pregnancy, median maternal serum esRAGE concentrations were more than three-fold higher in patients with preeclampsia (200 ng/l) than in controls (63 ng/l) (P < 0.01). Furthermore, esRAGE levels positively correlated with age, blood pressure, creatinine, adiponectin, and C-reactive protein, whereas a negative correlation existed with fasting insulin and the homeostasis model assessment of insulin resistance index. In multivariate analyses, homeostasis model assessment of insulin resistance and C-reactive protein independently predicted esRAGE serum levels and explained 44% of the variation in esRAGE concentrations. Surprisingly, median esRAGE concentrations 6 months after delivery were significantly lower in former patients with preeclampsia (270 ng/l) than in controls (342 ng/l) in contrast to the results obtained during pregnancy.
CONCLUSION: We showed that maternal esRAGE concentrations are significantly increased in patients with preeclampsia during pregnancy. Here, insulin sensitivity and inflammatory status independently predict serum esRAGE levels.
Authors:
Mathias Fasshauer; Jeannette Seeger; Theresa Waldeyer; Susanne Schrey; Thomas Ebert; Ulrike Lossner; Matthias Bluher; Michael Stumvoll; Renaldo Faber; Holger Stepan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  26     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-12-19     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1824-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine III, University of Leipzig, Ph.-Rosenthal Strasse 27, Leipzig, Germany. mathias.fasshauer@medizin.uni-leipzig.de
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adolescent
Adult
Blood Preservation
C-Reactive Protein / metabolism
Creatinine / blood
Enzyme-Linked Immunosorbent Assay
Female
Glycosylation End Products, Advanced / blood
Humans
Hypertension, Pregnancy-Induced / blood*,  diagnosis*
Insulin Resistance
Multivariate Analysis
Pre-Eclampsia / blood*,  diagnosis*
Predictive Value of Tests
Pregnancy
Receptors, Immunologic / blood*
Young Adult
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Glycosylation End Products, Advanced; 0/Receptors, Immunologic; 0/advanced glycosylation end-product receptor; 60-27-5/Creatinine; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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