Document Detail

Endogenous pyrogen formation by human blood monocytes stimulated by polyriboinosinic acid:polyribocytidylic acid.
MedLine Citation:
PMID:  7680005     Owner:  NLM     Status:  MEDLINE    
The pyrogenic response to supernatants from human blood monocytes stimulated with polyriboinosinic acid:polyribocytidylic acid (poly I:C) was characteristic of a response to endogenous pyrogen in that it was brief and monophasic, and was destroyed by heating the supernatants at 70 degrees C for 30 min. Pyrogen production was unimpaired when the incubations were carried out in the presence of cycloheximide (50 micrograms/ml; an inhibitor of protein synthesis) or indomethacin (50 micrograms/ml; an inhibitor of prostaglandin synthesis). Also, neither interferon, interleukins, tumor necrosis factor nor prostaglandin E2 were detectable in the supernatants from the poly I:C-stimulated human monocytes.
S J Won; M T Lin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experientia     Volume:  49     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-29     Completed Date:  1993-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  157-9     Citation Subset:  IM    
Department of Microbiology, National Cheng Kung University Medical College, Tainan City, Taiwan, Republic of China.
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MeSH Terms
Biological Assay
Body Temperature
Cytokines / biosynthesis*
Dinoprostone / biosynthesis
Interferons / biosynthesis
Monocytes / metabolism*
Poly I-C / pharmacology*
Pyrogens / biosynthesis*
Reg. No./Substance:
0/Cytokines; 0/Pyrogens; 24939-03-5/Poly I-C; 363-24-6/Dinoprostone; 9008-11-1/Interferons

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