| Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain. | |
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MedLine Citation:
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PMID: 19812918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pituitary adenylate cyclase activating polypeptide is a pleiotropic neuropeptide. We previously showed that heterozygous PACAP gene knockout (PACAP(+/-)) mice had larger infarct volumes and worse neurological scores after middle cerebral artery occlusion (MCAO). However, the relationship between endogenous PACAP levels and edema in the ischemic brain has not yet been evaluated. In this study, the formation of edema in the ischemic brain as well as cerebral blood flow was compared between PACAP(+/-) and wild-type (PACAP(+/+)) mice. The amount of brain edema was calculated by subtracting the contralateral volume from the ipsilateral volume 24 h after permanent MCAO. PACAP(+/-) mice showed significantly greater brain edema than PACAP(+/+) mice. To investigate the effects of endogenous PACAP on blood flow during ischemia, cerebral blood flow in the ipsilateral and the contralateral cortices was compared between PACAP(+/-) and PACAP(+/+) mice for 25 min after ischemia. With a two-dimensional laser Doppler perfusion imaging system, the blood flow in the ipsilateral and contralateral cortices was shown to be similar in PACAP(+/-) and PACAP(+/+) mice during ischemia. These results suggest that endogenous PACAP suppresses the formation of edema in the ischemic brain. |
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Authors:
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Tomoya Nakamachi; Hirokazu Ohtaki; Sachiko Yofu; Kenji Dohi; Jun Watanabe; Hiroyoshi Mori; Atsushi Sato; Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba; Seiji Shioda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurochirurgica. Supplement Volume: 106 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir. Suppl. Publication Date: 2010 |
Date Detail:
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Created Date: 2009-10-08 Completed Date: 2010-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962752 Medline TA: Acta Neurochir Suppl Country: Austria |
Other Details:
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Languages: eng Pagination: 43-6 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Showa University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Edema / etiology*, genetics*, pathology Cerebral Cortex / physiopathology Cerebrovascular Circulation / genetics Disease Models, Animal Functional Laterality / physiology Infarction, Middle Cerebral Artery / complications* Mice Mice, Inbred C57BL Mice, Knockout Pituitary Adenylate Cyclase-Activating Polypeptide / deficiency, metabolism* Regional Blood Flow / genetics Time Factors Ultrasonography, Doppler / methods |
| Chemical | |
Reg. No./Substance:
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0/Pituitary Adenylate Cyclase-Activating Polypeptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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