| Endogenous opioid-like substances in perinatal asphyxia and cerebral injury due to anoxia. | |
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MedLine Citation:
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PMID: 7913434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perinatal asphyxia is one of the major causes of cerebral injury in neonates. It may be due to the increased endogenous opioid-like substances (OLS) in the body. The levels of three OLS, namely leucine-enkephalin (LEK), beta-endorphin (beta-EP) and dynorphin A1-13 (DynoA1-13) of 44 cases with neonatal asphyxia were studied by radioimmunoassay. The OLS level in plasma and cerebral spinal fluid (CSF) were higher in asphyxiated group than those in the control group, especially in asphyxiated cases with fetal distress. The OLS levels of CSF were also higher in cases with cerebral injury than in those without cerebral injury, while the levels of OLS in plasma had no difference in these two groups. The relationship between OLS levels and asphyxia and cerebral injury is also discussed. |
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Authors:
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L Cao; P D Qian; L J Jing; Q J Liang; Z Z Zhao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 106 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-08-16 Completed Date: 1994-08-16 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: CHINA |
Other Details:
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Languages: eng Pagination: 783-7 Citation Subset: IM |
Affiliation:
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Pediatric Department, Hebei Provincial Hospital, Shijiazhuang. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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etiology,
metabolism* Cerebral Hemorrhage / etiology, metabolism* Dynorphins / metabolism Enkephalin, Leucine / metabolism* Female Fetal Hypoxia / complications Humans Infant, Newborn Male Peptide Fragments / metabolism Pregnancy beta-Endorphin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 58822-25-6/Enkephalin, Leucine; 60617-12-1/beta-Endorphin; 72957-38-1/dynorphin (1-13); 74913-18-1/Dynorphins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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