Document Detail

Endogenous opioid-like substances in perinatal asphyxia and cerebral injury due to anoxia.
MedLine Citation:
PMID:  7913434     Owner:  NLM     Status:  MEDLINE    
Perinatal asphyxia is one of the major causes of cerebral injury in neonates. It may be due to the increased endogenous opioid-like substances (OLS) in the body. The levels of three OLS, namely leucine-enkephalin (LEK), beta-endorphin (beta-EP) and dynorphin A1-13 (DynoA1-13) of 44 cases with neonatal asphyxia were studied by radioimmunoassay. The OLS level in plasma and cerebral spinal fluid (CSF) were higher in asphyxiated group than those in the control group, especially in asphyxiated cases with fetal distress. The OLS levels of CSF were also higher in cases with cerebral injury than in those without cerebral injury, while the levels of OLS in plasma had no difference in these two groups. The relationship between OLS levels and asphyxia and cerebral injury is also discussed.
L Cao; P D Qian; L J Jing; Q J Liang; Z Z Zhao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  106     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-08-16     Completed Date:  1994-08-16     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  783-7     Citation Subset:  IM    
Pediatric Department, Hebei Provincial Hospital, Shijiazhuang.
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MeSH Terms
Asphyxia Neonatorum / etiology,  metabolism*
Cerebral Hemorrhage / etiology,  metabolism*
Dynorphins / metabolism
Enkephalin, Leucine / metabolism*
Fetal Hypoxia / complications
Infant, Newborn
Peptide Fragments / metabolism
beta-Endorphin / metabolism
Reg. No./Substance:
0/Peptide Fragments; 58822-25-6/Enkephalin, Leucine; 60617-12-1/beta-Endorphin; 72957-38-1/dynorphin (1-13); 74913-18-1/Dynorphins

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