Document Detail

Endogenous opioid effects on abdominal muscle activity during inspiratory loading.
MedLine Citation:
PMID:  2246159     Owner:  NLM     Status:  MEDLINE    
In a previous study in unanesthetized goats, we demonstrated that continuous naloxone (NLX) administration during inspiratory flow-resistive loading (IRL) significantly increased tidal volume (VT) but not diaphragm electromyogram (EMGdi). End-expiratory gastric pressure did increase with NLX, implying that increased abdominal muscle activity may have accounted for the NLX effect. In the current study we directly tested the hypothesis that endogenous opioid elaboration depresses the abdominal muscle response to a continuous inspiratory flow-resistive load. In seven unanesthetized goats, VT, arterial blood gases, EMGdi, and EMG activity of external oblique (EMGeo), transversus abdominis (EMGta), and external intercostal (EMGei) muscles were monitored. IRL (50 cmH2O.l-1.s) was continued for 3 h, after which NLX (0.1 mg/kg) or saline was given. Our results showed that VT decreased from 323 +/- 32 (SE) ml at baseline to 260 +/- 16 ml 5 min after the load was imposed (P less than 0.05) and further decreased to 229 +/- 18 and 217 +/- 15 ml by 120 and 180 min, respectively (180 vs. 5 min, P less than 0.05). EMGdi increased from 62 +/- 5 to 83 +/- 4% max at 5 min (P less than 0.05) but was unchanged thereafter. In contrast, for this same time period EMGeo increased from 35 +/- 5 to 58 +/- 11% max but decreased from 67 +/- 11% max at 120 min to 37 +/- 5% max at 180 min (P less than 0.05). NLX administration resulted in significant increases in EMGeo (91% above 180-min value). In contrast, EMGdi increased minimally after NLX (15% above 180-min value).(ABSTRACT TRUNCATED AT 250 WORDS)
A T Scardella; J J Petrozzino; M Mandel; N H Edelman; T V Santiago
Related Documents :
4055569 - Role of hilar nerve afferents in hyperpnea of exercise.
17186299 - The influence of inspiratory and expiratory muscle training upon rowing performance.
9517599 - Low load inspiratory muscle training increases diaphragmatic fiber dimensions in rats.
8325069 - Inspiratory muscle training and respiratory sensation during treadmill exercise.
7650839 - Effects of l- and dl-carnitine on patients with impaired exercise tolerance.
11915979 - Alternans in qrs amplitude during ventricular tachycardia.
6706759 - Adrenocortical responses to maximal exercise in moderate-altitude natives at 447 torr.
24149349 - The effects of vibration during maximal graded cycling exercise: a pilot study.
21206679 - Effects of aerobic exercise and resistance training on lipid profiles and inflammation ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  69     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-08     Completed Date:  1991-01-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1104-9     Citation Subset:  IM    
Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903-0019.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abdomen / physiology
Diaphragm / physiology
Electrodes, Implanted
Endorphins / physiology*
Naloxone / pharmacology
Pulmonary Gas Exchange
Respiration / physiology
Respiratory Muscles / physiology*
Tidal Volume
Grant Support
Reg. No./Substance:
0/Endorphins; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Depression of posttetanic twitch potentiation by low calcium and calcium channel antagonists.
Next Document:  Leaky intra-acinar arteries in rat lungs perfused with hydrogen peroxide.