Document Detail

Endogenous opiates in the mediation of early meal-induced jejunal absorption of water and electrolytes.
MedLine Citation:
PMID:  2910124     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the role of endogenous opiates in mediating meal-stimulated jejunal absorption. Jejunal Thiry-Vella loops, 25 cm long, were studied in awake conditioned dogs, using luminal perfusion with carbon-14 polyethylene glycol. Fluxes of water, sodium, and chloride were calculated every 15 minutes over a 1-hour basal period, followed by a 3-hour experimental period. The animals were divided into four groups: control, naloxone, meal, and meal plus naloxone. In the control and naloxone groups, the fluxes did not change over the 4-hour observation period. Meal alone immediately stimulated the absorption of water and electrolytes in the Thiry-Vella loop (p less than 0.05). The addition of naloxone infusion to the meal stimulus resulted in significantly reduced absorption during the first hour after the meal (p less than 0.05). We concluded that endogenous opiates play a role in meal-stimulated jejunal absorption.
J A Bastidas; C J Yeo; R E Schmieg; M J Zinner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  157     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  AIM; IM    
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
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MeSH Terms
Chlorides / metabolism*
Endorphins / physiology*
Intestinal Absorption*
Jejunum / physiology*
Naloxone / pharmacology
Sodium / metabolism*
Time Factors
Water / metabolism*
Reg. No./Substance:
0/Chlorides; 0/Endorphins; 465-65-6/Naloxone; 7440-23-5/Sodium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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