Document Detail

Endogenous nociceptin modulates diet preference independent of motivation and reward.
MedLine Citation:
PMID:  19138695     Owner:  NLM     Status:  MEDLINE    
Previous studies show that the opioid peptide nociceptin stimulates food intake. Here, we studied nociceptin receptor knockout (NOP KO) mice in various behavioral paradigms designed to differentiate psychological and physiological loci at which endogenous nociceptin might control feeding. When presented a choice under food restriction, NOP KO mice displayed reduced preference for high sucrose diet, but lower intake of high fat diet under no-choice conditions. These responses were absent under ad libitum feeding conditions. Conditioned place preference to high fat diet under food-deprived conditions was unaltered in NOP KO mice, suggesting no difference in reward responses. Furthermore, operant food self-administration under a variety of conditions showed no genotype-dependent differences, suggesting no differences in the motivational properties of food. Taste reactivity to sucrose was unchanged in NOP KO mice, though NOP KO mice had altered aversive reactions to quinine solutions under ad libitum feeding, suggesting minor differences in the affective impact of palatable and unpalatable tastants. Although NOP KO mice re-fed following food-deprivation showed normal increases in plasma glucose and insulin, multidimensional scaling analysis showed that the relationship between these measures, body weight and plasma leptin was substantially disrupted in NOP KO, particularly in fasted mice. Additionally, the typical positive relationship between body weight and plasma leptin was considerably weaker in NOP KO mice. Together, these findings suggest that endogenous nociceptin differentially modulates diet preference depending on macronutrient content and homeostatic state, independently of the motivating, rewarding or orosensory properties of food, but may involve metabolic or postingestive processes.
Miwako Koizumi; Barbara Cagniard; Niall P Murphy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-24
Journal Detail:
Title:  Physiology & behavior     Volume:  97     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-06-23     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-13     Citation Subset:  IM    
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MeSH Terms
Blood Glucose
Body Weight
Conditioning, Operant
Dietary Fats
Dietary Sucrose
Drinking Behavior / physiology
Food Deprivation
Food Preferences / physiology*,  psychology*
Insulin / blood
Leptin / blood
Mice, Inbred C57BL
Mice, Knockout
Opioid Peptides / genetics,  physiology*
Receptors, Opioid / genetics
Taste Perception / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Dietary Sucrose; 0/Insulin; 0/Leptin; 0/Opioid Peptides; 0/Receptors, Opioid; 0/nociceptin; 0/nociceptin receptor

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