| Endogenous nitric oxide in the upper airways of premature and term infants. | |
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MedLine Citation:
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PMID: 9401519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concentrations of endogenous nitric oxide (NO) were measured in premature (n = 18) and term infants (n = 7). Nasal gas was aspirated continuously and after timed occlusions, 15 s and 60 s, by a fast-response chemiluminescence analyser. The sampling flow rate was 20 ml min-1. Typical NO recordings consisted of plateaux and postocclusive peaks. In term infants peak NO concentrations (60 s occlusion) were 2.71 +/- 0.44 parts per million (ppm) within 10 min after birth, increasing (p < 0.05) to 3.81 +/- 0.25 ppm at 4-7 d postnatally. Peak NO values (15 s occlusion) averaged 1.22 +/- 0.16 ppm in premature infants (postconceptional age 25-37 weeks, body weight 623-2844 g) and the NO concentrations increased significantly with postconceptional age (p < 0.05). Nasal excretion rate, estimated from plateau NO concentrations and sampling flow rate, was 0.10 +/- 0.01 nmol min-1 kg-1 in both groups. We conclude that premature and term newborn infants excrete considerable amounts of NO in the upper airways, with hitherto not fully known functions. |
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Authors:
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U Schedin; M Norman; L E Gustafsson; B Jonsson; C Frostell |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 86 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-01-13 Completed Date: 1998-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 1229-35 Citation Subset: IM |
Affiliation:
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Division of Anaesthesia and Intensive Care, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cross-Sectional Studies Female Humans Infant Infant, Newborn Infant, Premature / physiology* Longitudinal Studies Lung / metabolism, physiology Male Nasal Mucosa / chemistry* Nitric Oxide / analysis*, physiology |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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Acta Paediatr. 1999 Apr;88(4):471-2
[PMID:
10342552
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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