| Endogenous nitric oxide enhances the light-response of cones during light-adaptation in the rat retina. | |
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MedLine Citation:
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PMID: 20951158 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The electroretinogram (ERG) is a non-invasive indicator of retinal function. Light flashes evoke a cornea-negative a-wave followed by a cornea-positive b-wave. Light-adaptation is known to increase the amplitude of cone-dependent b-waves. To identify the underlying mechanism, we recorded rat cone photoresponses in situ, using intravitreally-injected glutamate to block synaptic transmission and intense paired-flash stimuli to isolate cone a-waves. Steady adapting illumination caused a progressive increase in cone a-wave amplitude, which was suppressed in a dose-dependent manner by intravitreal CPTIO, a nitric oxide scavenger. We conclude that light-adaptation causes release of nitric oxide, which enhances the cone photoresponse. |
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Authors:
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Masaki Sato; Teruya Ohtsuka; William K Stell |
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Publication Detail:
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Type: Journal Article Date: 2010-10-14 |
Journal Detail:
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Title: Vision research Volume: 51 ISSN: 1878-5646 ISO Abbreviation: Vision Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417402 Medline TA: Vision Res Country: England |
Other Details:
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Languages: eng Pagination: 131-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010. Published by Elsevier Ltd. |
Affiliation:
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Biology Research Division, Graduate School of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510 Chiba, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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